An Alternative Approach to Wound Healing Field; New Composite Films from Natural Polymers for Mupirocin Dermal Delivery

Overview

Journal Saudi Pharm J

Specialty Pharmacy

Date 2019 Jul 13

PMID 31297030

Citations 24

Authors

Neslihan Ustundag Okur

Nesrin Hokenek

Mehmet Evren Okur

Sule Ayla

Aysegul Yoltas

Panoraia I Siafaka

Erdal Cevher

Affiliations

Soon will be listed here.

Abstract

In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release properties. Solvent evaporation method was used for films preparation. Preliminary studies involved FT-IR spectroscopy and Scanning Electron Microscopy to specify interactions and morphology. Thickness, tensile strength and water uptake in phosphate buffer saline were evaluated whereas release studies were also performed. drug release studies demonstrated that mupirocin release was improved. bioadhesion and permeation studies using Balb-c mice were performed to check the suitability of the films. Antimicrobial ability was evaluated by agar well diffusion tests. Finally, excisional wound model applied to test the wound healing effect and evaluated macroscopic and histopathologically. One formulation was found more effective compared to the market product for wound healing at Balb-c mice.

Citing Articles

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