Blood Transcriptome and Clonal T-cell Correlates of Response and Non-response to Eltrombopag Therapy in a Cohort of Patients with Chronic Immune Thrombocytopenia

Overview

Journal Haematologica

Specialty Hematology

Date 2019 Jul 13

PMID 31296576

Citations 7

Authors

Haiyu Zhang

Bing M Zhang

Xiangqian Guo

Liwen Xu

Xiaoqing You

Robert B West

James B Bussel

James L Zehnder

Affiliations

Soon will be listed here.

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References

Kuter D, Gminski D, Rosenberg R . Transforming growth factor beta inhibits megakaryocyte growth and endomitosis. Blood. 1992; 79(3):619-26. View

Chapin J, Lee C, Zhang H, Zehnder J, Bussel J . Gender and duration of disease differentiate responses to rituximab-dexamethasone therapy in adults with immune thrombocytopenia. Am J Hematol. 2016; 91(9):907-11. DOI: 10.1002/ajh.24434. View

Angenieux C, Maitre B, Eckly A, Lanza F, Gachet C, de la Salle H . Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity. PLoS One. 2016; 11(1):e0148064. PMC: 4726520. DOI: 10.1371/journal.pone.0148064. View

Beck A, Weng Z, Witten D, Zhu S, Foley J, Lacroute P . 3'-end sequencing for expression quantification (3SEQ) from archival tumor samples. PLoS One. 2010; 5(1):e8768. PMC: 2808244. DOI: 10.1371/journal.pone.0008768. View

Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold D . Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2008; 113(11):2386-93. DOI: 10.1182/blood-2008-07-162503. View

Stasi R, Del Poeta G, Stipa E, Evangelista M, Trawinska M, Cooper N . Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood. 2007; 110(8):2924-30. DOI: 10.1182/blood-2007-02-068999. View

Rowley J, Oler A, Tolley N, Hunter B, Low E, Nix D . Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011; 118(14):e101-11. PMC: 3193274. DOI: 10.1182/blood-2011-03-339705. View

Li X, Zhong H, Bao W, Boulad N, Evangelista J, Haider M . Defective regulatory B-cell compartment in patients with immune thrombocytopenia. Blood. 2012; 120(16):3318-25. PMC: 3476542. DOI: 10.1182/blood-2012-05-432575. View

Fogarty P, Rick M, Zeng W, Risitano A, Dunbar C, Bussel J . T cell receptor VB repertoire diversity in patients with immune thrombocytopenia following splenectomy. Clin Exp Immunol. 2003; 133(3):461-6. PMC: 1808786. DOI: 10.1046/j.1365-2249.2003.02239.x. View

10.

Sakamaki S, Hirayama Y, Matsunaga T, Kuroda H, Kusakabe T, Akiyama T . Transforming growth factor-beta1 (TGF-beta1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with.... Blood. 1999; 94(6):1961-70. View

11.

Guo X, Zhu S, Brunner A, van de Rijn M, West R . Next generation sequencing-based expression profiling identifies signatures from benign stromal proliferations that define stromal components of breast cancer. Breast Cancer Res. 2013; 15(6):R117. PMC: 3978842. DOI: 10.1186/bcr3586. View

12.

Bao W, Bussel J, Heck S, He W, Karpoff M, Boulad N . Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents. Blood. 2010; 116(22):4639-45. PMC: 2996119. DOI: 10.1182/blood-2010-04-281717. View

13.

Liu X, Liu S, Feng Q, Liu X, Li G, Sheng Z . Thrombopoietin receptor agonists shift the balance of Fcγ receptors toward inhibitory receptor IIb on monocytes in ITP. Blood. 2016; 128(6):852-61. DOI: 10.1182/blood-2016-01-690727. View

14.

Gonzalez-Lopez T, Pascual C, Alvarez-Roman M, Fernandez-Fuertes F, Sanchez-Gonzalez B, Caparros I . Successful discontinuation of eltrombopag after complete remission in patients with primary immune thrombocytopenia. Am J Hematol. 2014; 90(3):E40-3. DOI: 10.1002/ajh.23900. View

15.

Xu L, You X, Zheng P, Zhang B, Gupta P, Lavori P . Methodologic Considerations in the Application of Next-Generation Sequencing of Human TRB Repertoires for Clinical Use. J Mol Diagn. 2016; 19(1):72-83. PMC: 5225307. DOI: 10.1016/j.jmoldx.2016.07.009. View