IL-1 Family Cytokine Regulation of Vascular Permeability and Angiogenesis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 Jul 12

PMID 31293586

Citations 124

Authors

Erin Fahey

Sarah L Doyle

Affiliations

Soon will be listed here.

Abstract

The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory responses both in response to and acting as danger signals. It has long been established that IL-1 is capable of simultaneously regulating inflammation and angiogenesis, indeed one of IL-1's earliest names was haemopoeitn-1 due to its pro-angiogenic effects. Other IL-1 family cytokines are also known to have roles in mediating angiogenesis, either directly or indirectly via induction of proangiogenic factors such as VEGF. Of note, some of these family members appear to have directly opposing effects in different tissues and pathologies. Here we will review what is known about how the various IL-1 family members regulate vascular permeability and angiogenic function in a range of different tissues, and describe some of the mechanisms employed to achieve these effects.

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