Body Composition, Metabolic Characteristics, and Insulin Resistance in Obese and Nonobese Women with Polycystic Ovary Syndrome

Overview

Journal J Hum Reprod Sci

Date 2019 Jul 12

PMID 31293320

Citations 15

Authors

Anil Satyaraddi

Kripa Elizabeth Cherian

Nitin Kapoor

Aleyamma Thaiparambil Kunjummen

Mohan S Kamath

Nihal Thomas

Thomas V Paul

Affiliations

Soon will be listed here.

Abstract

Objectives: The objective was to compare body composition, metabolic characteristics, and insulin resistance between obese (body mass index [BMI] ≥25 kg/m) polycystic ovary syndrome (PCOS) and nonobese PCOS (BMI <25 kg/m) women and their age- and BMI-matched controls.

Materials And Methods: A total of 81 PCOS women (Rotterdam criteria) (obese - 42; nonobese - 39) and 86 controls (obese - 42; nonobese -44) were recruited in this cross-sectional study. All women underwent a detailed assessment of clinical, anthropometric, and metabolic parameters, insulin resistance indices, and body composition measurements with visceral adipose tissue assessment (VAT) (dual-energy X-ray absorptiometry scan).

Results: Of PCOS women, 27% (80% - obese PCOS; 20% - nonobese PCOS) were diagnosed with metabolic syndrome (International Diabetes Federation criteria), 35% of PCOS women (46% - obese PCOS; 54% - nonobese PCOS) had impaired glucose tolerance, and 7% of PCOS women (2/3 - obese PCOS; 1/3 - nonobese PCOS) had diabetes mellitus. Insulin resistance was seen in about 80% in obese PCOS women and 20% in nonobese PCOS women based on various insulin resistance indices such as fasting insulin (≥12.2 μU/ml), Homeostasis Model Assessment-Insulin Resistance (≥2.5), and Quantitative Insulin Sensitivity Check Index (<0.33). Total body fat, estimated (Est.) VAT, and corrected Est. VAT (corrected for body weight) were significantly increased ( = 0.0001) in both obese and nonobese PCOS women when compared to those of their age- and BMI-matched controls. However, corrected Est. VAT (corrected for body weight) was not significantly different between obese and nonobese PCOS women.

Conclusion: Both obese and nonobese PCOS women when compared with their age- and BMI-matched controls were metabolically worse and had more visceral adiposity. Nonobese PCOS poses similar risk as that of obese PCOS in having similar amount of VAT (corrected for body weight).

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