Estrogen Regulates the Satellite Cell Compartment in Females

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2019 Jul 11

PMID 31291574

Citations 51

Authors

Brittany C Collins

Robert W Arpke

Alexie A Larson

Cory W Baumann

Ning Xie

Christine A Cabelka

Nardina L Nash

Hanna-Kaarina Juppi

Eija K Laakkonen

Sarianna Sipila

Vuokko Kovanen

Espen E Spangenburg

Michael Kyba

Dawn A Lowe

Affiliations

Soon will be listed here.

Abstract

Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely compromises the maintenance of muscle stem cells (i.e., satellite cells) as well as impairs self-renewal and differentiation into muscle fibers. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor α and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females.

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