Diabetic Neuropathy Research: from Mouse Models to Targets for Treatment

Overview

Journal Neural Regen Res

Date 2019 Jul 11

PMID 31290436

Citations 12

Authors

Vuong M Pham

Shinji Matsumura

Tayo Katano

Nobuo Funatsu

Seiji Ito

Affiliations

Soon will be listed here.

Abstract

Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.

Citing Articles

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