Dimensional Changes Following Alveolar Ridge Preservation in the Posterior Area Using Bovine-derived Xenografts and Collagen Membrane Compared to Spontaneous Healing: a 6-month Randomized Controlled Clinical Trial

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2019 Jul 10

PMID 31286260

Citations 12

Authors

Vincenzo Iorio-Siciliano

Luca Ramaglia

Andrea Blasi

Paolo Bucci

Paolo Nuzzolo

Francesco Riccitiello

Michele Nicolo

Affiliations

Soon will be listed here.

Abstract

Objectives: To assess dimensional changes following alveolar ridge preservation using bovine-derived xenograft with 10% collagen and collagen membrane compared to ridge preservation by means of bovine-derived xenograft particles and collagen membrane or spontaneous healing in posterior sites.

Materials And Methods: Forty subjects with 40 posterior teeth or roots candidate to extraction and presenting integrity of alveolar bone walls were randomly allocated into three groups. Patients of test group were treated by ridge preservation technique using bovine-derived xenograft with 10% collagen and collagen membrane; patients of control group 1 were treated by means of bovine-derived xenograft particles and collagen membrane while in patients of control group 2, no grafting was performed. Changes in vertical and horizontal bone dimensions were compared at baseline and after 6-month observation time.

Results: Statistically significant differences between baseline and 6 month were observed in all groups in terms of vertical and horizontal bone resorption (p < 0.001), except for vertical resorption in control group 2. After 6-month intergroup comparisons showed not statistically significant changes between test and control groups in terms of alveolar bone changes (p > 0.05).

Conclusions: Within the limits of this study, the sites grafted using bovine-derived xenograft with 10% collagen in combination with a collagen membrane showed no statistical differences in terms of vertical and horizontal bone resorption compared to control groups.

Clinical Relevance: Ridge preservation in posterior area failed to show clinically relevant benefits in sites presenting integrity of alveolar bone walls and adequate buccal bone wall thickness.

Citing Articles

The Microbial Diversity and Biofilm Characteristics of d-PTFE Membranes Used for Socket Preservation: A Randomized Controlled Clinical Trial.

Franovic B, candrlic M, Blaskovic M, Renko I, Komar Milas K, Markova-Car E J Funct Biomater. 2025; 16(2).

PMID: 39997574 PMC: 11856730. DOI: 10.3390/jfb16020040.

Autologous platelet concentrates in alveolar ridge preservation: A systematic review with meta-analyses.

Siawasch S, Yu J, Castro A, Dhondt R, Teughels W, Temmerman A Periodontol 2000. 2024; 97(1):104-130.

PMID: 39345008 PMC: 11808431. DOI: 10.1111/prd.12609.

Efficacy of Alveolar Ridge Preservation in Periodontally Compromised Molar Extraction Sites: A Systematic Review and Meta-Analysis.

Fok M, Pelekos G, Jin L J Clin Med. 2024; 13(5).

PMID: 38592010 PMC: 10931845. DOI: 10.3390/jcm13051198.

The Long-Term Esthetic and Radiographic Outcome of Implants Placed in the Anterior Maxilla after Ridge Preservation, Combining Bovine Xenograft with Collagen Matrix.

Batas L, Xanthopoulou V, Gnigou M, Vagdouti T, Fragkioudakis I, Vouros I Dent J (Basel). 2024; 12(3).

PMID: 38534304 PMC: 10968737. DOI: 10.3390/dj12030080.

Effectiveness of a collagen matrix seal and xenograft in alveolar ridge preservation: an experimental study in dogs.

Han H, Lee J, Oh S, Cho Y, Kim S Sci Rep. 2024; 14(1):163.

PMID: 38168516 PMC: 10762190. DOI: 10.1038/s41598-023-50370-3.

References

Crespi R, Cappare P, Gherlone E . Magnesium-enriched hydroxyapatite compared to calcium sulfate in the healing of human extraction sockets: radiographic and histomorphometric evaluation at 3 months. J Periodontol. 2009; 80(2):210-8. DOI: 10.1902/jop.2009.080400. View

Milani S, Dal Pozzo L, Rasperini G, Sforza C, Dellavia C . Deproteinized bovine bone remodeling pattern in alveolar socket: a clinical immunohistological evaluation. Clin Oral Implants Res. 2014; 27(3):295-302. DOI: 10.1111/clr.12535. View

Barone A, Orlando B, Cingano L, Marconcini S, Derchi G, Covani U . A randomized clinical trial to evaluate and compare implants placed in augmented versus non-augmented extraction sockets: 3-year results. J Periodontol. 2011; 83(7):836-46. DOI: 10.1902/jop.2011.110205. View

Fickl S, Zuhr O, Wachtel H, Stappert C, Stein J, Hurzeler M . Dimensional changes of the alveolar ridge contour after different socket preservation techniques. J Clin Periodontol. 2008; 35(10):906-13. DOI: 10.1111/j.1600-051X.2008.01305.x. View

Iorio-Siciliano V, Blasi A, Nicolo M, Iorio-Siciliano A, Riccitiello F, Ramaglia L . Clinical Outcomes of Socket Preservation Using Bovine-Derived Xenograft Collagen and Collagen Membrane Post-Tooth Extraction: A 6-Month Randomized Controlled Clinical Trial. Int J Periodontics Restorative Dent. 2017; 37(5):e290-e296. DOI: 10.11607/prd.2474. View

Schropp L, Wenzel A, Kostopoulos L, Karring T . Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent. 2003; 23(4):313-23. View

Koutouzis T, Lipton D . Regenerative Needs Following Alveolar Ridge Preservation Procedures in Compromised and Noncompromised Extraction Sockets: A Cone Beam Computed Tomography Study. Int J Oral Maxillofac Implants. 2016; 31(4):849-54. DOI: 10.11607/jomi.4437. View

Fickl S, Schneider D, Zuhr O, Hinze M, Ender A, Jung R . Dimensional changes of the ridge contour after socket preservation and buccal overbuilding: an animal study. J Clin Periodontol. 2009; 36(5):442-8. DOI: 10.1111/j.1600-051X.2009.01381.x. View

Tan W, Wong T, Wong M, Lang N . A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012; 23 Suppl 5:1-21. DOI: 10.1111/j.1600-0501.2011.02375.x. View

10.

Araujo M, Lindhe J . Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005; 32(2):212-8. DOI: 10.1111/j.1600-051X.2005.00642.x. View

11.

Darby I, Chen S, Buser D . Ridge preservation techniques for implant therapy. Int J Oral Maxillofac Implants. 2009; 24 Suppl:260-71. View

12.

Coomes A, Mealey B, Huynh-Ba G, Barboza-Arguello C, Moore W, Cochran D . Buccal bone formation after flapless extraction: a randomized, controlled clinical trial comparing recombinant human bone morphogenetic protein 2/absorbable collagen carrier and collagen sponge alone. J Periodontol. 2013; 85(4):525-35. DOI: 10.1902/jop.2013.130207. View

13.

Fickl S, Zuhr O, Wachtel H, Kebschull M, Hurzeler M . Hard tissue alterations after socket preservation with additional buccal overbuilding: a study in the beagle dog. J Clin Periodontol. 2009; 36(10):898-904. DOI: 10.1111/j.1600-051X.2009.01463.x. View

14.

Cardaropoli G, Araujo M, Lindhe J . Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs. J Clin Periodontol. 2003; 30(9):809-18. DOI: 10.1034/j.1600-051x.2003.00366.x. View

15.

Sbordone C, Toti P, Ramaglia L, Guidetti F, Sbordone L, Martuscelli R . A 5-year clinical and computerized tomographic implant follow-up in sinus-lifted maxillae and native bone. Clin Oral Implants Res. 2013; 25(9):1056-64. DOI: 10.1111/clr.12222. View

16.

Engler-Hamm D, Cheung W, Yen A, Stark P, Griffin T . Ridge preservation using a composite bone graft and a bioabsorbable membrane with and without primary wound closure: a comparative clinical trial. J Periodontol. 2010; 82(3):377-87. DOI: 10.1902/jop.2010.090342. View

17.

Flugge T, Nelson K, Nack C, Stricker A, Nahles S . 2-Dimensional changes of the soft tissue profile of augmented and non-augmented human extraction sockets: a randomized pilot study. J Clin Periodontol. 2015; 42(4):390-7. DOI: 10.1111/jcpe.12386. View

18.

Iasella J, Greenwell H, Miller R, Hill M, Drisko C, Bohra A . Ridge preservation with freeze-dried bone allograft and a collagen membrane compared to extraction alone for implant site development: a clinical and histologic study in humans. J Periodontol. 2003; 74(7):990-9. DOI: 10.1902/jop.2003.74.7.990. View

19.

Matarasso S, Salvi G, Iorio Siciliano V, Cafiero C, Blasi A, Lang N . Dimensional ridge alterations following immediate implant placement in molar extraction sites: a six-month prospective cohort study with surgical re-entry. Clin Oral Implants Res. 2009; 20(10):1092-8. DOI: 10.1111/j.1600-0501.2009.01803.x. View

20.

Wu I, Bakhshalian N, Galaustian R, Naini R, Min S, Freire M . Retrospective Analysis of the Outcome of Ridge Preservation with Anorganic Bovine Bone Mineral: Marginal Bone Level at Implants Placed Following Healing of Grafted Extraction Sockets. Int J Periodontics Restorative Dent. 2018; 39(1):131-140. DOI: 10.11607/prd.3308. View