Gene Mapping and Molecular Analysis of Hereditarynon-polyposis Colorectal Cancer (Lynch Syndrome)using Systems Biological Approaches

Overview

Journal Bioinformation

Specialty Biology

Date 2019 Jul 10

PMID 31285644

Citations 1

Authors

Mahmood Rasool

Sajjad Karim

Muhammad Imran Naseer

Peter Natesan Pushparaj

Adel Abuzenadah

Mohammed Hussein Al-Qahtani

Affiliations

Soon will be listed here.

Abstract

Hereditary non-polyposis colorectal cancer (HNPCC) also known as Lynch Syndrome (LS), is a hereditary form of colorectal cancer (CRC). LSis caused by mutations in the mismatch repair (MMR) genes, mostly in MLH1, MSH2, MSH6 and PMS2. Identification of these gene mutations is essential to diagnose CRC, especially at a young age to increase the survival rate. Using open target platform, we have performed genetic association studies to analyze the different genes involved in the LS and to obtain target for disease evidence. We have also analyzed upstream regulators as target molecules in the data sets. We discovered that MLH1, MSH2, MSH6, PMS2, MLH3, EPCAM, TGFBR2, FBXO11 and PRSS58 were showing most association in LS. Our findings may further enhance the understanding of the hereditaryform of CRC.

Citing Articles

Research progress on the biological basis of Traditional Chinese Medicine syndromes of gastrointestinal cancers.

Guo T, Zhao S, Zhu W, Zhou H, Cheng H Heliyon. 2023; 9(11):e20653.

PMID: 38027682 PMC: 10643116. DOI: 10.1016/j.heliyon.2023.e20653.

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