Correlation of Human Papillomavirus 16 and 18 with Cervical Cancer and Their Diagnosis Methods in Iranian Women: A Systematic Review and Meta-analysis

Background: Human papillomavirus (HPV) is a sexually transmitted virus and related to the development of cervical cancer (CC). To determine the association between high-risk HPV types and CC, we undertook a systematic review and meta-analysis of recently reported prevalence of HPV16 and 18 in Iranian women identified with cervical infections.

Materials And Methods: Prevalence studies were identified between 2002 and 2018 using several databases including Medline, Web of Science, Embase, Google Scholar, Iranmedex, and Scientific Information Database.

Results: For patients with CC, 57% (95% confidence interval [95% CI] = 43.7%-70.4%) were HPV positive, 48.5% (95% CI = 31.8%-65.2%) were HPV16 and 12.5% (95% CI = 8.8%-16.2%) were HPV18 positive.

Conclusion: The results from meta-analysis indicate a relatively high prevalence of high-risk HPV among women infected with CC.