3'-UTR Polymorphisms in the Vascular Endothelial Growth Factor Gene (VEGF) Contribute to Susceptibility to Recurrent Pregnancy Loss (RPL)

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Jul 10

PMID 31284523

Citations 12

Authors

Hui Jeong An

Ji Hyang Kim

Eun Hee Ahn

Young Ran Kim

Jung Oh Kim

Han Sung Park

Chang Soo Ryu

Eun-Gyo Kim

Sung Hwan Cho

Woo Sik Lee

Nam Keun Kim

Affiliations

Soon will be listed here.

Abstract

Numerous studies have examined the genetic association of vascular endothelial growth factor (VEGF) single nucleotide polymorphisms (SNPs) with recurrent pregnancy loss (RPL). However, of the four known SNPs in the 3'-untranslated region (3'-UTR) of , three SNPs-namely rs3025040 (1451C>T), rs10434 (1612G>A), and rs3025053 (1725G>A)-remain poorly characterized with regard to RPL. Herein, we evaluated the association between these three SNPs in the 3'-UTR and RPL susceptibility. We analyzed 3'-UTR gene variants in with and without RPL using TaqMan allelic discrimination. There were significant differences in the genotype frequencies of 1612G>A (GA: adjusted odds ratio (AOR), 0.652; 95% confidence interval (CI), 0.447-0.951; = 0.026) and 1725G>A (GA: AOR, 0.503; 95% CI, 0.229-0.848; = 0.010) in RPL patients vs. controls. Our results indicate that the 1612G>A and 1725G>A polymorphisms in the 3'-UTR of are associated with RPL susceptibility in Korean women. These data suggest that 3'-UTR polymorphisms may be utilized as biomarkers for the detection of RPL risk and prevention.

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