Stem Cell-Derived Hepatocyte-Like Cells As Model for Viral Hepatitis Research

Overview

Journal Stem Cells Int

Publisher Wiley

Specialty Cell Biology

Date 2019 Jul 9

PMID 31281392

Citations 13

Authors

Jingjing Wang

Bingqian Qu

Fang Zhang

Cindy Zhang

Wanyan Deng

Viet Loan Dao Thi

Yuchen Xia

Affiliations

Soon will be listed here.

Abstract

Viral hepatitis, the leading cause of liver diseases worldwide, is induced upon infection with hepatotropic viruses, including hepatitis A, B, C, D, and E virus. Due to their obligate intracellular lifestyles, culture systems for efficient viral replication are vital. Although basic and translational research on viral hepatitis has been performed for many years, conventional hepatocellular culture systems are not optimal. These studies have greatly benefited from recent efforts on improving cell culture models for virus replication and infection studies. Here we summarize the use of human stem cell-derived hepatocyte-like cells for hepatotropic virus infection studies, including the dissection of virus-host interactions and virus-induced pathogenesis as well as the identification and validation of novel antiviral agents.

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