The Use of Allogenic Stromal Vascular Fraction (SVF) Cells in Degenerative Joint Disease of the Spine in Dogs

Overview

Journal In Vivo

Specialty Oncology

Date 2019 Jul 8

PMID 31280199

Citations 11

Authors

Jerzy Kemilew

Aleksandra Sobczynska-Rak

Beata Zylinska

Tomasz Szponder

Beata Nowicka

Barbara Urban

Affiliations

Soon will be listed here.

Abstract

Background/aim: Stem cells are widely used in regenerative medicine and in clinical practice for the treatment of damaged nerve tissue, myocytes, tendons, and ligaments. The aim of the study was to monitor VEGF levels after the administration of allogenic cellular material (SVF) in the course of treatment of dogs suffering from degenerative joint disease in the spinal region.

Materials And Methods: The study was conducted on 10 dogs of both genders, aged between 6 and 13 years in which allogenic stromal vascular fraction of stem cells (SVF) was administered intravenously. The control group was composed of 10 clinically healthy dogs. Before treatment and after 2- and 8-week intervals blood samples were obtained from the study group dogs in order to determine VEGF levels via immunoenzymatic test.

Results: in a few days after the therapy, alleviation of pain symptoms and reduction of lameness were noticed. The VEGF level in 2 weeks after the therapy was significantly elevated (median: 38.77 pg/ml), while in 8 weeks a decrease was observed (median: 18.37 pg/ml). Conlusion: Administration of allogenic stem cells has a positive influence on elevation of the VEGF levels in the blood serum of affected animals as well as their regeneration capacity.

Citing Articles

The Use of Stromal Vascular Fraction in Long Bone Defect Healing in Sheep.

Pappa E, Barbagianni M, Georgiou S, Athanasiou L, Psalla D, Vekios D Animals (Basel). 2023; 13(18).

PMID: 37760271 PMC: 10525334. DOI: 10.3390/ani13182871.

Stem Cells in Domestic Animals: Applications in Health and Production.

Iacono E, Merlo B Animals (Basel). 2022; 12(20).

PMID: 36290139 PMC: 9597731. DOI: 10.3390/ani12202753.

Stromal Vascular Fraction for Osteoarthritis of the Knee Regenerative Engineering.

Ude C, Shah S, Ogueri K, Nair L, Laurencin C Regen Eng Transl Med. 2022; 8(2):210-224.

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Clinical applications of adipose-derived stromal vascular fraction in veterinary practice.

Sharun K, Jambagi K, Kumar R, Gugjoo M, Pawde A, Tuli H Vet Q. 2022; 42(1):151-166.

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Manufacturing Mesenchymal Stromal Cells for the Treatment of Osteoarthritis in Canine Patients: Challenges and Recommendations.

Ivanovska A, Wang M, Arshaghi T, Shaw G, Alves J, Byrne A Front Vet Sci. 2022; 9:897150.

PMID: 35754551 PMC: 9230578. DOI: 10.3389/fvets.2022.897150.

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