» Articles » PMID: 31273286

Visceral Adiposity Index (VAI), Lipid Accumulation Product (LAP), and Product of Triglycerides and Glucose (TyG) to Discriminate Prediabetes and Diabetes

Overview
Journal Sci Rep
Specialty Science
Date 2019 Jul 6
PMID 31273286
Citations 104
Authors
Affiliations
Soon will be listed here.
Abstract

The present study evaluated the ability of the visceral adiposity index (VAI), the lipid accumulation product (LAP), and product of triglycerides and glucose (TyG), three novel, insulin resistance-related markers, to discriminate prediabetes/diabetes in the general German population. Altogether 2,045 Germans (31-72 years, 53.3% women) without known diabetes and a history of Myocardial Infarction (MI)/stroke from the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study were eligible. The discriminatory accuracy of the markers for oral glucose tolerance test (OGTT)-defined prediabetes/diabetes according to the American Diabetes Association (ADA) criteria was assessed by the area under the receiver operating characteristic (ROC) curve (AUC). The Youden Index (YI) was used to determine optimal cut-off values, and a non-parametric ROC regression was used to examine whether the discriminatory accuracy varied by sex and age. 365 men (38.2%) and 257 women (23.6%) were newly diagnosed with prediabetes/diabetes. AUCs for TyG, LAP and VAI were 0.762 (95% CI 0.740-0.784), 0.743 (95% CI 0.720-0.765), and 0.687 (95% CI 0.662-0.712), respectively. The optimal cut-off values for the LAP and TyG were 56.70 and 8.75 in men, and 30.40 and 8.53 in women. In conclusion, TyG and LAP provide good discrimination of persons with prediabetes/diabetes.

Citing Articles

Association between five novel anthropometric indices and erectile dysfunction in US adults from NHANES database.

Xu N, Zou H, Xu H, Chen Y, Wen Q, Xing X Sci Rep. 2025; 15(1):1625.

PMID: 39794403 PMC: 11723986. DOI: 10.1038/s41598-024-80878-1.


Association between lipid accumulation product and chronic obstructive pulmonary disease: a cross-sectional analysis.

Zhang S, Li Z, Zeng Y, Jiang J, Lei W, Chen S BMC Pulm Med. 2025; 25(1):6.

PMID: 39762812 PMC: 11702100. DOI: 10.1186/s12890-024-03465-0.


Perspective from NHANES data: synergistic effects of visceral adiposity index and lipid accumulation products on diabetes risk.

He J, Chen L Sci Rep. 2025; 15(1):258.

PMID: 39747273 PMC: 11696142. DOI: 10.1038/s41598-024-84034-7.


Predictive Power of Anthropometric Measures and Indices in Assessing Nutrition-Related Risk Using the Geriatric Nutritional Risk Index in Elderly Patients: A Cross-Sectional Study.

Nowak J, Jabczyk M, Skrzypek M, Brukalo K, Hudzik B, Zubelewicz-Szkodzinska B Med Sci Monit. 2024; 30:e946316.

PMID: 39722437 PMC: 11686918. DOI: 10.12659/MSM.946316.


Mediating role of triglyceride-glucose index and its derivatives in the relationship between central obesity and Hashimoto thyroiditis in type 2 diabetes.

Zhai Y, Lin C, Li J, Qiu H, Wu F, Wang Y Lipids Health Dis. 2024; 23(1):411.

PMID: 39702130 PMC: 11657283. DOI: 10.1186/s12944-024-02402-8.


References
1.
Khoo C, Sairazi S, Taslim S, Gardner D, Wu Y, Lee J . Ethnicity modifies the relationships of insulin resistance, inflammation, and adiponectin with obesity in a multiethnic Asian population. Diabetes Care. 2011; 34(5):1120-6. PMC: 3114514. DOI: 10.2337/dc10-2097. View

2.
Simental-Mendia L, Rodriguez-Moran M, Guerrero-Romero F . The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab Syndr Relat Disord. 2008; 6(4):299-304. DOI: 10.1089/met.2008.0034. View

3.
Ji B, Qu H, Wang H, Wei H, Deng H . Association Between the Visceral Adiposity Index and Homeostatic Model Assessment of Insulin Resistance in Participants With Normal Waist Circumference. Angiology. 2017; 68(8):716-721. DOI: 10.1177/0003319716682120. View

4.
Eriksson K, Lindgarde F . Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmö feasibility study. Diabetologia. 1991; 34(12):891-8. DOI: 10.1007/BF00400196. View

5.
Tuomilehto J, Lindstrom J, Eriksson J, Valle T, Hamalainen H, Ilanne-Parikka P . Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001; 344(18):1343-50. DOI: 10.1056/NEJM200105033441801. View