Massive Synchronous B-cell Necrosis Causing Type 1 (insulin-dependent) Diabetes--a Unique Histopathological Case Report

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1988 Jan 1

PMID 3127259

Citations 3

Authors

A K Foulis

N D Francis

M A Farquharson

A Boylston

Affiliations

Soon will be listed here.

Abstract

A 22-year-old Chinese male died in hyperglycaemic coma following a 36-h illness. The only significant pathological findings were in the pancreas where there was a heavy diffuse infiltrate of lymphocytes admixed with numerous eosinophils, macrophages and polymorphs. There appeared to have been massive, recent, synchronous necrosis of insulin-secreting B cells with no destruction of any other pancreatic parenchymal cells. The biochemical findings of severe hyperglycaemia, insulinopoenia, but a normal glycosylated HbA1 were compatible with an acute onset to the patient's diabetes. These features contrast with the very much slower destruction of B cells associated with insulitis seen in "classical" Type 1 (insulin-dependent) diabetes.

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