Response to the Letter from Garcia-Montojo and Colleagues Concerning Our Paper Entitled, Quantitative Analysis of Human Endogenous Retrovirus-K Transcripts in Postmortem Premotor Cortex Fails to Confirm Elevated Expression of HERV-K RNA In...

Overview

Journal Acta Neuropathol Commun

Publisher Biomed Central

Specialty Neurology

Date 2019 Jul 5

PMID 31269988

Citations 4

Authors

Jeremy A Garson

Louise Usher

Ammar Al-Chalabi

Jim Huggett

Edmund F Day

Adele L McCormick

Affiliations

Soon will be listed here.

Citing Articles

HSV-1 and Endogenous Retroviruses as Risk Factors in Demyelination.

Bello-Morales R, Andreu S, Ripa I, Lopez-Guerrero J Int J Mol Sci. 2021; 22(11).

PMID: 34072259 PMC: 8199333. DOI: 10.3390/ijms22115738.

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.

Padmanabhan Nair V, Liu H, Ciceri G, Jungverdorben J, Frishman G, Tchieu J Cell Stem Cell. 2021; 28(9):1566-1581.e8.

PMID: 33951478 PMC: 8419085. DOI: 10.1016/j.stem.2021.04.009.

Endogenous Retroviruses in Nervous System Disorders.

Groger V, Emmer A, Staege M, Cynis H Pharmaceuticals (Basel). 2021; 14(1).

PMID: 33467098 PMC: 7829834. DOI: 10.3390/ph14010070.

A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins.

Rigogliuso G, Biniossek M, Goodier J, Mayer B, Pereira G, Schilling O Mob DNA. 2019; 10:36.

PMID: 31462935 PMC: 6707001. DOI: 10.1186/s13100-019-0178-z.

References

Garson J, Usher L, Al-Chalabi A, Huggett J, Day E, McCormick A . Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosis. Acta Neuropathol Commun. 2019; 7(1):45. PMC: 6421708. DOI: 10.1186/s40478-019-0698-2. View

Bustin S, Benes V, Garson J, Hellemans J, Huggett J, Kubista M . The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009; 55(4):611-22. DOI: 10.1373/clinchem.2008.112797. View

Hohman T, Chibnik L, Bush W, Jefferson A, De Jaeger P, Thornton-Wells T . GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension. Neurotox Res. 2015; 28(3):232-8. PMC: 4625986. DOI: 10.1007/s12640-015-9541-0. View

Wang X, Chen Y, Wang X, Lu L . Genetic regulatory network analysis for app based on genetical genomics approach. Exp Aging Res. 2010; 36(1):79-93. DOI: 10.1080/03610730903418729. View

Rydbirk R, Folke J, Winge K, Aznar S, Pakkenberg B, Brudek T . Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases. Sci Rep. 2016; 6:37116. PMC: 5112547. DOI: 10.1038/srep37116. View

Kwok J, Hallupp M, Loy C, Chan D, Woo J, Mellick G . GSK3B polymorphisms alter transcription and splicing in Parkinson's disease. Ann Neurol. 2005; 58(6):829-39. DOI: 10.1002/ana.20691. View

Sonntag K, Tejada G, Subburaju S, Berretta S, Benes F, Woo T . Limited predictability of postmortem human brain tissue quality by RNA integrity numbers. J Neurochem. 2016; 138(1):53-9. PMC: 4915987. DOI: 10.1111/jnc.13637. View

Mayer J, Harz C, Sanchez L, Pereira G, Maldener E, Heras S . Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins. Mol Neurodegener. 2018; 13(1):39. PMC: 6091006. DOI: 10.1186/s13024-018-0275-3. View

Vermeulen J, De Preter K, Lefever S, Nuytens J, De Vloed F, Derveaux S . Measurable impact of RNA quality on gene expression results from quantitative PCR. Nucleic Acids Res. 2011; 39(9):e63. PMC: 3089491. DOI: 10.1093/nar/gkr065. View

10.

Armentero M, Sinforiani E, Ghezzi C, Bazzini E, Levandis G, Ambrosi G . Peripheral expression of key regulatory kinases in Alzheimer's disease and Parkinson's disease. Neurobiol Aging. 2010; 32(12):2142-51. DOI: 10.1016/j.neurobiolaging.2010.01.004. View

11.

Durrenberger P, Fernando F, Magliozzi R, Kashefi S, Bonnert T, Ferrer I . Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study. Acta Neuropathol. 2012; 124(6):893-903. DOI: 10.1007/s00401-012-1027-z. View

12.

Fleige S, Pfaffl M . RNA integrity and the effect on the real-time qRT-PCR performance. Mol Aspects Med. 2006; 27(2-3):126-39. DOI: 10.1016/j.mam.2005.12.003. View

13.

Hye A, Kerr F, Archer N, Foy C, Poppe M, Brown R . Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease. Neurosci Lett. 2004; 373(1):1-4. DOI: 10.1016/j.neulet.2004.10.031. View

14.

Kap M, Oomen M, Arshad S, de Jong B, Riegman P . Fit for purpose frozen tissue collections by RNA integrity number-based quality control assurance at the Erasmus MC tissue bank. Biopreserv Biobank. 2014; 12(2):81-90. DOI: 10.1089/bio.2013.0051. View

15.

Li W, Lee M, Henderson L, Tyagi R, Bachani M, Steiner J . Human endogenous retrovirus-K contributes to motor neuron disease. Sci Transl Med. 2015; 7(307):307ra153. PMC: 6344353. DOI: 10.1126/scitranslmed.aac8201. View

16.

Garcia-Montojo M, Li W, Nath A . Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR. Acta Neuropathol Commun. 2019; 7(1):101. PMC: 6607509. DOI: 10.1186/s40478-019-0753-z. View