How Ocular Surface Microbiota Debuts in Type 2 Diabetes Mellitus

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2019 Jul 3

PMID 31263683

Citations 33

Authors

Siqi Li

Guoguo Yi

Hui Peng

Zhenhao Li

Shuze Chen

Huimin Zhong

Yifan Chen

Zhoucheng Wang

Qixin Deng

Min Fu

Affiliations

Soon will be listed here.

Abstract

High glucose represents a good environment for bacterial growth on the skin, on the ocular surface (OS) and in the tears of type 2 diabetes mellitus (T2DM) patients, affecting the conjunctival bacterial community. This study aimed to investigate the OS bacterial flora of T2DM patients and healthy subjects using 16S rRNA sequencing-based bacterial identification. Among 23 healthy subjects (CON) and 31 T2DM patients, 54 eyes were examined to investigate the OS bacterial community. Factors potentially affecting the microbial growth were controlled. Results showed the OS microbiota presented higher diversity in the T2DM group than in the CON group. Bioinformatic analysis showed a lower abundance of and a higher abundance of at the phyla level as well as a significantly increased abundance of and at the genus level in the T2DM group. The difference in OS microbiota at taxonomic level was associated with Ocular Surface Disease Index and course of T2DM. These findings indicate the OS flora in T2DM patients is significantly different from that in healthy subjects, which may be closely associated with OS discomfort and course of T2DM.

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