Managing Female Pelvic Floor Disorders: a Medical Device Review and Appraisal

Overview

Journal Interface Focus

Specialty Biology

Date 2019 Jul 3

PMID 31263534

Citations 3

Authors

Shelby A Powers

Lindsey K Burleson

Johanna L Hannan

Affiliations

Soon will be listed here.

Abstract

Pelvic floor disorders (PFDs) will affect most women during their lifetime. Sequelae such as pelvic organ prolapse, stress urinary incontinence, chronic pain and dyspareunia significantly impact overall quality of life. Interventions to manage or eliminate symptoms from PFDs aim to restore support of the pelvic floor. Pessaries have been used to mechanically counteract PFDs for thousands of years, but do not offer a cure. By contrast, surgically implanted grafts or mesh offer patients a more permanent resolution but have been in wide use within the pelvis for less than 30 years. In this perspective review, we provide an overview of the main theories underpinning PFD pathogenesis and the animal models used to investigate it. We highlight the clinical outcomes of mesh and grafts before exploring studies performed to elucidate tissue level effects and bioengineering considerations. Considering recent turmoil surrounding transvaginal mesh, the role of pessaries, an impermanent method, is examined as a means to address patients with PFDs.

Citing Articles

Vaginal Cuff Dehiscence and Small Intestinal Prolapse in a Middle-Aged Woman Due to Ring Pessary Use.

Meng R, Fang Z, Fu J, Cai Q, Shen Y, Hu Y Int J Womens Health. 2024; 16:2025-2031.

PMID: 39629296 PMC: 11611743. DOI: 10.2147/IJWH.S484688.

Pelvic Floor Dysfunction among Reproductive-Age Women in Israel: Prevalence and Attitudes-A Cross-Sectional Study.

Fisher-Yosef T, Lidsky Sachs D, Edel S, Nammouz H, Zoabi A, Adler L Healthcare (Basel). 2024; 12(3).

PMID: 38338275 PMC: 10855918. DOI: 10.3390/healthcare12030390.

Development of 3D Printed Biodegradable Mesh with Antimicrobial Properties for Pelvic Organ Prolapse.

Ren J, Murray R, Wong C, Qin J, Chen M, Totsika M Polymers (Basel). 2022; 14(4).

PMID: 35215676 PMC: 8877663. DOI: 10.3390/polym14040763.

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