Epidemiological Determinants of Advanced Prostate Cancer in Elderly Men in the United States

Overview

Journal Clin Med Insights Oncol

Publisher Sage Publications

Specialty Oncology

Date 2019 Jul 3

PMID 31263375

Citations 5

Authors

Jinani Jayasekera

Eberechukwu Onukwugha

Christopher Cadham

Sarah Tom

Donna Harrington

Michael Naslund

Affiliations

Soon will be listed here.

Abstract

In this study, we examined the effects of individual-level and area-level characteristics on advanced prostate cancer diagnosis among Medicare eligible older men (ages 70+ years). We analyzed patients from the linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database (2000-2007) linked to US Census and County Business Patterns data. Cluster-adjusted logistic regression models were used to quantify the effects of individual preventive health behavior, clinical and demographic characteristics, area-level health services supply, and socioeconomic characteristics on stage at diagnosis. The fully adjusted model was used to estimate county-specific effects and predicted probabilities of advanced prostate cancer. In the adjusted analyses, low intensity of annual prostate-specific antigen (PSA) testing and other preventive health behavior, high comorbidity, African American race, and lower county socioeconomic and health services supply characteristics were statistically significantly associated with a higher likelihood of distant prostate cancer diagnosis. The fully adjusted predicted proportions of advanced prostate cancer diagnosis across 158 counties ranged from 3% to 15% (mean: 6%, SD: 7%). County-level socioeconomic and health services supply characteristics, individual-level preventive health behavior, demographic and clinical characteristics are determinants of advanced stage prostate cancer diagnosis among older Medicare beneficiaries; other health care-related factors such as family history, lifestyle choices, and health-seeking behavior should also be considered as explanatory factors.

Citing Articles

Neighborhood Disadvantage and Prostate Tumor Aggressiveness among African American and European American Men.

Boyle J, Yau J, Slade J, Butts D, Wimbush J, Park J Cancer Epidemiol Biomarkers Prev. 2024; 33(10):1318-1326.

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Neighborhood Disadvantage and Prostate Tumor RNA Expression of Stress-Related Genes.

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The role of mesolevel characteristics of the health care system and socioeconomic factors on health care use - results of a scoping review.

Bammert P, Schuttig W, Novelli A, Iashchenko I, Spallek J, Blume M Int J Equity Health. 2024; 23(1):37.

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Aktary M, Shewchuk B, Wang Q, Hyndman E, Shack L, Robson P Prostate Cancer. 2023; 2023:4426167.

PMID: 38020965 PMC: 10656198. DOI: 10.1155/2023/4426167.

Using health insurance claims data to assess long-term disease progression in a prostate cancer cohort.

Khan S, Vohra S, Farnan L, Elmore S, Toumbou K, K C M Prostate. 2022; 82(15):1447-1455.

PMID: 35880605 PMC: 9492636. DOI: 10.1002/pros.24418.

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