Evaluation of Vitamin D Levels and Response to Therapy of Childhood Migraine

Overview

Journal Medicina (Kaunas)

Publisher MDPI

Specialty General Medicine

Date 2019 Jul 3

PMID 31261815

Citations 6

Authors

Betul Kilic

Mustafa Kilic

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Vitamin D deficiency and insufficiency are related with many neurological diseases such as migraine. The aim of this study was to investigate whether pediatric migraine is associated with vitamin D deficiency and the effect of vitamin D therapy on the frequency, duration, severity of migraine attacks, and Pediatric Migraine Disability Assessment (PedMIDAS).

Materials And Methods: We retrospectively examined the patients' levels of calcium, phosphorus, parathyroid hormone, alkaline phosphatase, and 25-OH vitamin D of 92 pediatric migraine patients. The patients were divided into two groups: Group 1, which had low vitamin D levels and received vitamin D therapy, and group 2, which had normal vitamin D levels and did not receive vitamin D therapy. Migraine severity measured by the visual analog scale (VAS), migraine frequency, and duration as well as scores on the PedMIDAS questionnaire were compared with regard to the 25-OH vitamin D levels. In addition, pre- and posttreatment pedMIDAS scores, VAS, migraine frequency, and duration were compared with baseline values.

Results: A total of 34.7% patients had vitamin D insufficiency (vitamin D levels between 10 and 20 ng/mL), whereas 10.8% had vitamin D deficiency (vitamin D levels < 10 ng/mL). Migraine frequency, migraine duration, and PedMIDAS scores were significantly higher in the group 1 than group 2 ( = 0.004, = 0.008, and = 0.001). After vitamin D therapy at sixth months of supplementation, migraine duration was reported statistically significant shorter (p < 0.001) and the migraine frequency, VAS scores, and pedMIDAS scores were statistically significant lower compared with baseline values in group 1 ( < 0.001).

Conclusion: We found a marked correlation between pediatric migraine and vitamin D levels. Vitamin D therapy was beneficial in migraine pediatric patients.

Citing Articles

Pediatric Headache Patients Are at High Risk of Vitamin D Insufficiency.

Deschenes E, Do J, Tsampalieros A, Webster R, Whitley N, Ward L J Child Neurol. 2024; 40(2):91-98.

PMID: 39380442 PMC: 11783970. DOI: 10.1177/08830738241284057.

Vitamin D in Central Nervous System: Implications for Neurological Disorders.

Sailike B, Onzhanova Z, Akbay B, Tokay T, Molnar F Int J Mol Sci. 2024; 25(14).

PMID: 39063051 PMC: 11277055. DOI: 10.3390/ijms25147809.

Can flunarizine be used routinely as the first option for childhood headache treatment?: Flunarizine and childhood headache.

Cirakli S Medicine (Baltimore). 2022; 101(28):e29265.

PMID: 35839040 PMC: 11132379. DOI: 10.1097/MD.0000000000029265.

The Vitamin D Role in Preventing Primary Headache in Adult and Pediatric Population.

DellIsola G, Tulli E, Sica R, Vinti V, Mencaroni E, Di Cara G J Clin Med. 2021; 10(24).

PMID: 34945279 PMC: 8709239. DOI: 10.3390/jcm10245983.

Metabolic Aspects of Migraine: Association With Obesity and Diabetes Mellitus.

Rivera-Mancilla E, Al-Hassany L, Villalon C, MaassenVanDenBrink A Front Neurol. 2021; 12:686398.

PMID: 34177788 PMC: 8219973. DOI: 10.3389/fneur.2021.686398.

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