Carbohydrates in Human Milk and Body Composition of Term Infants During the First 12 Months of Lactation

Overview

Journal Nutrients

Date 2019 Jul 3

PMID 31261649

Citations 32

Authors

Zoya Gridneva

Alethea Rea

Wan Jun Tie

Ching Tat Lai

Sambavi Kugananthan

Leigh C Ward

Kevin Murray

Peter E Hartmann

Donna T Geddes

Affiliations

Soon will be listed here.

Abstract

Human milk (HM) carbohydrates may affect infant appetite regulation, breastfeeding patterns, and body composition (BC). We investigated relationships between concentrations/calculated daily intakes (CDI) of HM carbohydrates in first year postpartum and maternal/term infant BC, as well as breastfeeding parameters. BC of dyads ( = 20) was determined at 2, 5, 9, and/or 12 months postpartum using ultrasound skinfolds (infants) and bioelectrical impedance spectroscopy (infants/mothers). Breastfeeding frequency, 24-h milk intake and total carbohydrates (TCH) and lactose were measured to calculate HM oligosaccharides (HMO) concentration and CDI of carbohydrates. Statistical analysis used linear regression/mixed effects models; results were adjusted for multiple comparisons. Higher TCH concentrations were associated with greater infant length, weight, fat-free mass (FFM), and FFM index (FFMI), and decreased fat mass (FM), FM index (FMI), %FM and FM/FFM ratio. Higher HMO concentrations were associated with greater infant FFM and FFMI, and decreased FMI, %FM, and FM/FFM ratio. Higher TCH CDI were associated with greater FM, FMI, %FM, and FM/FFM ratio, and decreased infant FFMI. Higher lactose CDI were associated with greater FM, FMI, %FM, and FM/FFM, ratio and decreased FFMI. Concentrations and intakes of HM carbohydrates differentially influence development of infant BC in the first 12 months postpartum, and may potentially influence risk of later obesity via modulation of BC.

Citing Articles

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References

Curran-Everett D . Multiple comparisons: philosophies and illustrations. Am J Physiol Regul Integr Comp Physiol. 2000; 279(1):R1-8. DOI: 10.1152/ajpregu.2000.279.1.R1. View

Butte N, Wong W, Hopkinson J, Smith E, Ellis K . Infant feeding mode affects early growth and body composition. Pediatrics. 2000; 106(6):1355-66. DOI: 10.1542/peds.106.6.1355. View

Chaturvedi P, Warren C, Altaye M, Morrow A, Ruiz-Palacios G, Pickering L . Fucosylated human milk oligosaccharides vary between individuals and over the course of lactation. Glycobiology. 2001; 11(5):365-72. DOI: 10.1093/glycob/11.5.365. View

Wells J, Cole T . Adjustment of fat-free mass and fat mass for height in children aged 8 y. Int J Obes Relat Metab Disord. 2002; 26(7):947-52. DOI: 10.1038/sj.ijo.0802027. View

Mitoulas L, Kent J, Cox D, Owens R, Sherriff J, Hartmann P . Variation in fat, lactose and protein in human milk over 24 h and throughout the first year of lactation. Br J Nutr. 2002; 88(1):29-37. DOI: 10.1079/BJNBJN2002579. View

Kent J, Mitoulas L, Cregan M, Ramsay D, Doherty D, Hartmann P . Volume and frequency of breastfeedings and fat content of breast milk throughout the day. Pediatrics. 2006; 117(3):e387-95. DOI: 10.1542/peds.2005-1417. View

Ninonuevo M, Park Y, Yin H, Zhang J, Ward R, Clowers B . A strategy for annotating the human milk glycome. J Agric Food Chem. 2006; 54(20):7471-80. DOI: 10.1021/jf0615810. View

Wells J, Chomtho S, Fewtrell M . Programming of body composition by early growth and nutrition. Proc Nutr Soc. 2007; 66(3):423-34. DOI: 10.1017/S0029665107005691. View

Binns C, Fraser M, Lee A, Scott J . Defining exclusive breastfeeding in Australia. J Paediatr Child Health. 2009; 45(4):174-80. DOI: 10.1111/j.1440-1754.2009.01478.x. View

10.

Nommsen L, Lovelady C, Heinig M, Lonnerdal B, Dewey K . Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 mo of lactation: the DARLING Study. Am J Clin Nutr. 1991; 53(2):457-65. DOI: 10.1093/ajcn/53.2.457. View

11.

VANITALLIE T, Yang M, Heymsfield S, Funk R, Boileau R . Height-normalized indices of the body's fat-free mass and fat mass: potentially useful indicators of nutritional status. Am J Clin Nutr. 1990; 52(6):953-9. DOI: 10.1093/ajcn/52.6.953. View

12.

Quinn E, Largado F, Power M, Kuzawa C . Predictors of breast milk macronutrient composition in Filipino mothers. Am J Hum Biol. 2012; 24(4):533-40. DOI: 10.1002/ajhb.22266. View

13.

Bode L . Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012; 22(9):1147-62. PMC: 3406618. DOI: 10.1093/glycob/cws074. View

14.

Fields D, Demerath E . Relationship of insulin, glucose, leptin, IL-6 and TNF-α in human breast milk with infant growth and body composition. Pediatr Obes. 2012; 7(4):304-12. PMC: 3393795. DOI: 10.1111/j.2047-6310.2012.00059.x. View

15.

Khan S, Hepworth A, Prime D, Lai C, Trengove N, Hartmann P . Variation in fat, lactose, and protein composition in breast milk over 24 hours: associations with infant feeding patterns. J Hum Lact. 2012; 29(1):81-9. DOI: 10.1177/0890334412448841. View

16.

Cederlund A, Kai-Larsen Y, Printz G, Yoshio H, Alvelius G, Lagercrantz H . Lactose in human breast milk an inducer of innate immunity with implications for a role in intestinal homeostasis. PLoS One. 2013; 8(1):e53876. PMC: 3542196. DOI: 10.1371/journal.pone.0053876. View

17.

Khan S, Prime D, Hepworth A, Lai C, Trengove N, Hartmann P . Investigation of short-term variations in term breast milk composition during repeated breast expression sessions. J Hum Lact. 2013; 29(2):196-204. DOI: 10.1177/0890334412470213. View

18.

Albalasmeh A, Berhe A, Ghezzehei T . A new method for rapid determination of carbohydrate and total carbon concentrations using UV spectrophotometry. Carbohydr Polym. 2013; 97(2):253-61. DOI: 10.1016/j.carbpol.2013.04.072. View

19.

Michaelsen K, Skafte L, Badsberg J, Jorgensen M . Variation in macronutrients in human bank milk: influencing factors and implications for human milk banking. J Pediatr Gastroenterol Nutr. 1990; 11(2):229-39. DOI: 10.1097/00005176-199008000-00013. View

20.

Malik V, Pan A, Willett W, Hu F . Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013; 98(4):1084-102. PMC: 3778861. DOI: 10.3945/ajcn.113.058362. View