The Changing Epidemiology of Primary Liver Cancer

Overview

Journal Curr Epidemiol Rep

Specialty Public Health

Date 2019 Jul 2

PMID 31259140

Citations 75

Authors

Jessica L Petrick

Katherine A McGlynn

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: In prior decades, liver cancer was viewed as a neoplasm that almost exclusively arose among high-risk populations in low- and middle-income countries. Incidence rates in some high-risk populations, however, have been declining, while rates in low-risk populations have been increasing, reflecting changes in underlying etiology. In this review, we highlight the evolving epidemiology of liver cancer, focusing on recent research and advances.

Recent Findings: Efforts to reduce or eliminate the risk associated with major risk factors such as hepatitis B virus (HBV), hepatitis C virus (HCV) and aflatoxin B (AFB) have met with some success. As opposed to these favorable trends, the joint epidemics of obesity and diabetes have begun to affect liver cancer rates around the world.

Summary: While there has been progress in combating the effects of some risk factors, the increasing prevalence of others poses a major threat to attempts to tackle the rising incidence of liver cancer globally.

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References

Plummer M, de Martel C, Vignat J, Ferlay J, Bray F, Franceschi S . Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health. 2016; 4(9):e609-16. DOI: 10.1016/S2214-109X(16)30143-7. View

Li D, Ren Y, Fierer D, Rutledge S, Shaikh O, Lo Re 3rd V . The short-term incidence of hepatocellular carcinoma is not increased after hepatitis C treatment with direct-acting antivirals: An ERCHIVES study. Hepatology. 2017; 67(6):2244-2253. DOI: 10.1002/hep.29707. View

Sun Z, Chen T, Thorgeirsson S, Zhan Q, Chen J, Park J . Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China. Carcinogenesis. 2013; 34(8):1800-5. PMC: 3731800. DOI: 10.1093/carcin/bgt007. View

Kanwal F, Kramer J, Asch S, Chayanupatkul M, Cao Y, El-Serag H . Risk of Hepatocellular Cancer in HCV Patients Treated With Direct-Acting Antiviral Agents. Gastroenterology. 2017; 153(4):996-1005.e1. DOI: 10.1053/j.gastro.2017.06.012. View

Ravi S, Axley P, Jones D, Kodali S, Simpson H, McGuire B . Unusually High Rates of Hepatocellular Carcinoma After Treatment With Direct-Acting Antiviral Therapy for Hepatitis C Related Cirrhosis. Gastroenterology. 2017; 152(4):911-912. DOI: 10.1053/j.gastro.2016.12.021. View

Sulkowski M, Gardiner D, Rodriguez-Torres M, Reddy K, Hassanein T, Jacobson I . Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med. 2014; 370(3):211-21. DOI: 10.1056/NEJMoa1306218. View

Elsharkawy A, El-Raziky M, El-Akel W, El-Saeed K, Eletreby R, Hassany M . Planning and prioritizing direct-acting antivirals treatment for HCV patients in countries with limited resources: Lessons from the Egyptian experience. J Hepatol. 2017; 68(4):691-698. DOI: 10.1016/j.jhep.2017.11.034. View

Nahon P, Bourcier V, Layese R, Audureau E, Cagnot C, Marcellin P . Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications. Gastroenterology. 2016; 152(1):142-156.e2. DOI: 10.1053/j.gastro.2016.09.009. View

Hagstrom H, Tynelius P, Rasmussen F . High BMI in late adolescence predicts future severe liver disease and hepatocellular carcinoma: a national, population-based cohort study in 1.2 million men. Gut. 2017; 67(8):1536-1542. DOI: 10.1136/gutjnl-2016-313622. View

10.

James W . The epidemiology of obesity: the size of the problem. J Intern Med. 2008; 263(4):336-52. DOI: 10.1111/j.1365-2796.2008.01922.x. View

11.

Ambade A, Mandrekar P . Oxidative stress and inflammation: essential partners in alcoholic liver disease. Int J Hepatol. 2012; 2012:853175. PMC: 3303590. DOI: 10.1155/2012/853175. View

12.

Schweitzer A, Horn J, Mikolajczyk R, Krause G, Ott J . Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet. 2015; 386(10003):1546-55. DOI: 10.1016/S0140-6736(15)61412-X. View

13.

El-Serag H, Hampel H, Javadi F . The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol. 2006; 4(3):369-80. DOI: 10.1016/j.cgh.2005.12.007. View

14.

Makarova-Rusher O, Altekruse S, McNeel T, Ulahannan S, Duffy A, Graubard B . Population attributable fractions of risk factors for hepatocellular carcinoma in the United States. Cancer. 2016; 122(11):1757-65. PMC: 5548177. DOI: 10.1002/cncr.29971. View

15.

Ramachandran A, Chamukuttan S, Shetty S, Arun N, Susairaj P . Obesity in Asia--is it different from rest of the world. Diabetes Metab Res Rev. 2013; 28 Suppl 2:47-51. DOI: 10.1002/dmrr.2353. View

16.

. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. Lancet Gastroenterol Hepatol. 2017; 2(3):161-176. DOI: 10.1016/S2468-1253(16)30181-9. View

17.

Petrick J, Braunlin M, Laversanne M, Valery P, Bray F, McGlynn K . International trends in liver cancer incidence, overall and by histologic subtype, 1978-2007. Int J Cancer. 2016; 139(7):1534-45. PMC: 5310166. DOI: 10.1002/ijc.30211. View

18.

Yang B, Petrick J, Kelly S, Graubard B, Freedman N, McGlynn K . Adiposity across the adult life course and incidence of primary liver cancer: The NIH-AARP cohort. Int J Cancer. 2017; 141(2):271-278. PMC: 5491533. DOI: 10.1002/ijc.30737. View

19.

Chen Y, Wang X, Wang J, Yan Z, Luo J . Excess body weight and the risk of primary liver cancer: an updated meta-analysis of prospective studies. Eur J Cancer. 2012; 48(14):2137-45. DOI: 10.1016/j.ejca.2012.02.063. View

20.

Fan J, Kim S, Wong V . New trends on obesity and NAFLD in Asia. J Hepatol. 2017; 67(4):862-873. DOI: 10.1016/j.jhep.2017.06.003. View