Photothermal Effect by 808-nm Laser Irradiation of Melanin: a Proof-of-concept Study of Photothermal Therapy Using B16-F10 Melanotic Melanoma Growing in BALB/c Mice

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2019 Jul 2

PMID 31259063

Citations 6

Authors

Lucas L Colombo

Silvia I Vanzulli

Alfonso Blazquez-Castro

Clara Sanchez Terrero

Juan C Stockert

Affiliations

Soon will be listed here.

Abstract

The photothermal effect is undergoing great interest due to advances in new photosensitizing materials and better-suited light sources, but studies are frequently hampered by the need to employ exogenous photothermal agents and expensive irradiation devices. Here we present a simple strategy based on direct NIR irradiation of the melanin pigment with a commercial 808-nm laser pointer. Proof-of-concept studies showed efficient photothermal effects on melanin and After NIR irradiation, BALB/c mice bearing B16-F10 melanotic melanoma tumors revealed severe histopathological damage and massive necrosis in melanin-containing tumor tissue, while surrounding healthy tissues showed no damage. Therefore, the feasibility of this approach may allow implementing direct procedures for photothermal therapy of pigmented tumors.

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