Antibiotics in 3D-printed Implants, Instruments and Materials: Benefits, Challenges and Future Directions

Overview

Journal J 3D Print Med

Specialty Biomedical Engineering

Date 2019 Jul 2

PMID 31258936

Citations 13

Authors

David H Ballard

Karthik Tappa

Christen J Boyer

Udayabhanu Jammalamadaka

Kavya Hemmanur

Jeffery A Weisman

Jonathan S Alexander

David K Mills

Pamela K Woodard

Affiliations

Soon will be listed here.

Abstract

3D printing is an additive manufacturing technology, which permits innovative approaches for incorporating antibiotics into 3D printed constructs. Antibiotic-incorporating applications in medicine have included medical implants, prostheses, along with procedural and surgical instruments. 3D-printed antibiotic-impregnated devices offer the advantages of increased surface area for drug distribution, sequential layers of antibiotics produced through layer-by-layer fabrication, and the ability to rapidly fabricate constructs based on patient-specific anatomies. To date, fused deposition modeling has been the main 3D printing method used to incorporate antibiotics, although inkjet and stereolithography techniques have also been described. This review offers a state-of-the-art summary of studies that incorporate antibiotics into 3D-printed constructs and summarizes the rationale, challenges, and future directions for the potential use of this technology in patient care.

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