Altered Spontaneous Brain Activity Patterns in Patients with Corneal Ulcer Using Amplitude of Low-frequency Fluctuation: An FMRI Study

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2019 Jul 2

PMID 31258645

Citations 7

Authors

Wen-Qing Shi

Wei Wu

Lei Ye

Nan Jiang

Wen-Feng Liu

Yong-Qiang Shu

Ting Su

Qi Lin

You-Lan Min

Biao Li

Pei-Wen Zhu

Yi Shao

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to investigate the altered spontaneous brain activity in patients with corneal ulcer (CU) through the amplitude of low-frequency fluctuation (ALFF) technique and the association with their visual performance. A total of 40 patients with CU and 40 healthy controls (HCs) matched for sex, age and educational level were enrolled. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed to examine the probands. Spontaneous cerebral activity variations were investigated using the ALFF technique. The average ALFF values of the CU patients and the HCs were classified by utilizing receiver operating characteristic (ROC) curves. Contrary to HCs, the CU patients had significantly lower ALFF values in the left cerebellar anterior lobe, right middle frontal gyrus and left middle frontal gyrus, but higher ALFF values in the right cerebellar inferior lobe, left cerebellar inferior lobe, left inferior temporal gyrus, right fusiform gyrus, left superior frontal gyrus, right angular gyrus and bilateral superior frontal gyrus. ROC curve analysis of each brain region indicated that the accuracy of ALFF value specificity between the CU and HCs of the area under the curve was perfect. In conclusion, abnormal spontaneous activities were detected in numerous brain regions of CU patients, which may provide useful information for understanding the dysfunction of CU. These activity changes in brain regions may be used as effective clinical indicators for CU.

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