BACH1 Orchestrates Lung Cancer Metastasis
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Two studies in this issue position the stabilization of the transcription factor BACH1 as a critical node in the metastasis of lung cancer and propose two new therapeutic approaches for this leading cause of cancer-related deaths (Lignitto et al., 2019; Wiel et al., 2019).
The role of ferroptosis in cardio-oncology.
Hou K, Liu L, Fang Z, Zong W, Sun D, Guo Z Arch Toxicol. 2024; 98(3):709-734.
PMID: 38182913 DOI: 10.1007/s00204-023-03665-3.
BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.
Amaral E, Namasivayam S, Queiroz A, Fukutani E, Hilligan K, Aberman K Nat Microbiol. 2023; 9(1):120-135.
PMID: 38066332 PMC: 10769877. DOI: 10.1038/s41564-023-01523-7.
Li Y, Niu L Sci Rep. 2022; 12(1):16040.
PMID: 36163484 PMC: 9512912. DOI: 10.1038/s41598-022-20040-x.
Harnessing the Therapeutic Potential of the Nrf2/Bach1 Signaling Pathway in Parkinson's Disease.
Ahuja M, Kaidery N, Dutta D, Attucks O, Kazakov E, Gazaryan I Antioxidants (Basel). 2022; 11(9).
PMID: 36139853 PMC: 9495572. DOI: 10.3390/antiox11091780.
Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
Ahuja M, Kaidery N, Attucks O, McDade E, Hushpulian D, Gaisin A Proc Natl Acad Sci U S A. 2021; 118(45).
PMID: 34737234 PMC: 8694049. DOI: 10.1073/pnas.2111643118.