Investigations of the Estrogen (ER-ICA-test) and the Progesterone Receptor in the Prostate and Prostatic Carcinoma on Immunohistochemical Basis

Overview

Journal Virchows Arch A Pathol Anat Histopathol

Specialty Anatomy & Histology

Date 1988 Jan 1

PMID 3125679

Citations 10

Authors

N Wernert

J Gerdes

V Loy

G Seitz

O Scherr

G Dhom

Affiliations

Soon will be listed here.

Abstract

Estrogen (ER) and Progesterone receptors (PR) were demonstrated immunohistochemically on frozen sections from 11 prostatectomy and 7 cystoprostatectomy specimens in the nuclei of various cell types. The periglandular fibrocytes and smooth muscle cells were extensively positive, the interglandular stromal cells were only partly so. Normal basal cells stained focally positive, hyperplastic basal cells stained extensively. The glandular secretory epithelium and atrophic glands were negative. The same findings were obtained in hyperplastic nodules. Both ER and PR also occurred in the urothelium of central prostatic ducts and of the prostatic urethra. The fibrous stroma around the ejaculatory ducts and seminal vesicles was extensively positive while the epithelium was negative. The smooth musculature of the seminal vesicles was only partly positive. On large field sections, the ER as well as the PR were numerically equally distributed throughout the inner zone of the prostate and the prostate proper. 12 prostatic carcinomas (G I-G III) were ER- and PR-negative. Estrogens may contribute to nodular hyperplasia by triggering a stromal proliferation with a secondary inductive epithelial growth. Obviously they do not act directly on prostatic carcinoma but inhibit growth via the hypophyseal-testicular axis. The biological significance of the PR in the prostate is unknown.

Citing Articles

Diagnostic and Prognostic Impact of Progesterone Receptor Immunohistochemistry: A Study Evaluating More Than 16,000 Tumors.

Viehweger F, Tinger L, Dum D, Gorbokon N, Menz A, Uhlig R Anal Cell Pathol (Amst). 2022; 2022:6412148.

PMID: 35992051 PMC: 9381849. DOI: 10.1155/2022/6412148.

Importance of Estrogenic Signaling and Its Mediated Receptors in Prostate Cancer.

Lau K, To K Int J Mol Sci. 2016; 17(9).

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High progesterone receptor expression in prostate cancer is associated with clinical failure.

Grindstad T, Andersen S, Al-Saad S, Donnem T, Kiselev Y, Nordahl Melbo-Jorgensen C PLoS One. 2015; 10(2):e0116691.

PMID: 25723513 PMC: 4344236. DOI: 10.1371/journal.pone.0116691.

A study to correlate histopathology, biochemical marker and immunohistochemical expression of sex-steroid receptors in prostatic growth.

Naskar S, Kundu S, Bhattacharyya N, Bhattacharyya P, Kundu A Indian J Med Paediatr Oncol. 2014; 35(1):40-3.

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Expression and function of the progesterone receptor in human prostate stroma provide novel insights to cell proliferation control.

Yu Y, Liu L, Xie N, Xue H, Fazli L, Buttyan R J Clin Endocrinol Metab. 2013; 98(7):2887-96.

PMID: 23666965 PMC: 4078099. DOI: 10.1210/jc.2012-4000.

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