Mangiferin Attenuates Myocardial Ischemia-Reperfusion Injury Via MAPK/Nrf-2/HO-1/NF-B and

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2019 Jun 29

PMID 31249649

Citations 14

Authors

Kun Liu

Fei Wang

Shuo Wang

Wei-Nan Li

Qing Ye

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the cardioprotective effect of mangiferin (MAF) and . Oxidative stress and inflammatory injury were detected in coronary artery ligation in rats and also in hypoxia-reoxygenation- (H/R-) induced H9c2 cells. MAF inhibited myocardial oxidative stress and proinflammatory cytokines in rats with coronary artery occlusion. The ST segment of MAF treatment groups also resumed. Triphenyltetrazolium chloride (TTC) staining and pathological analysis showed that MAF could significantly reduce myocardial injury. In vitro data showed that MAF could improve hypoxia/reoxygenation- (H/R-) induced H9c2 cell activity. In addition, MAF could significantly reduce oxidative stress and inflammatory pathway protein expression in H/R-induced H9c2 cells. This study has clarified the protective effects of MAF on myocardial injury and also confirmed that oxidative stress and inflammation were involved in the myocardial ischemia-reperfusion injury (I/R) model.

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