Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Overview

Journal Front Oncol

Specialty Oncology

Date 2019 Jun 28

PMID 31245292

Citations 55

Authors

Qingmei Ye

Kai Liu

Qun Shen

Qingyue Li

Jinghui Hao

Fangxuan Han

Ren-Wang Jiang

Affiliations

Soon will be listed here.

Abstract

Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have been developed, but most of them fail in clinical trials due to severely adverse effects. Recently, certain natural products have been reported to overcome MDR, including flavonoids which are abundant in plants, foods, and herbs. The structure of flavonoids can be abbreviated as C6-C3-C6 (C for carbon), and further categorized into flavonoids, iso-flavonoids and neo-flavonoids, according to their structural backbones. Flavonoids possess multiple bioactivities, and a growing body of research has indicated that both flavonoids and iso-flavonoids can either kill or re-sensitize conventional chemotherapeutics to resistant cancer cells. Here, we summarize the research and discuss the underlying mechanisms, concluding that these flavonoids do not function as specific regulators of target proteins, but rather as multi-functional agents that negatively regulate the key factors contributing to MDR.

Citing Articles

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