A Tropomyosin Receptor Kinase Family Protein, NTRK2 is a Potential Predictive Biomarker for Lung Adenocarcinoma

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2019 Jun 28

PMID 31245181

Citations 9

Authors

Xiang Wang

Zhijie Xu

Xi Chen

Xinxin Ren

Jie Wei

Shuyi Zhou

Xue Yang

Shuangshuang Zeng

Long Qian

Geting Wu

Zhicheng Gong

Yuanliang Yan

Affiliations

Soon will be listed here.

Abstract

Neurotrophic receptor tyrosine kinase 2 (NTRK2) is a member of the tropomyosin receptor kinase family associated with the tumor development. However, the detailed function of NTRK2 in lung cancer, especially in lung adenocarcinoma (LUAD), is still not fully understood. Here, we investigated the effects of NTRK2 on LUAD biology. Through analyzing bioinformatics data derived from several databases, such as Oncomine, Gene Expression Profiling Interactive Analysis and UALCAN, we found that NTRK2 expression was significantly decreased in LUAD tissues. Clinical data acquired from Wanderer database, which is linked to The Cancer Genome Atlas database, demonstrated that the expression and methylation site of NTRK2 were significantly related to the clinical characteristics and prognosis of LUAD. Furthermore, NTRK2 expression was increased remarkably after treatment with the protein kinase B (AKT) inhibitor MK2206 and the anticancer agent actinomycin D. Functional enrichment analysis of NTRK2-associated coexpression genes was further conducted. Together, our results suggested that downregulated NTRK2 might be used in the diagnostic and prognostic evaluation of LUAD patients, or as a potential therapeutic target for the treatment of LUAD.

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