Microwave Ablation Combined with Chemotherapy Improved Progression Free Survival of IV Stage Lung Adenocarcinoma Patients Compared with Chemotherapy Alone

Overview

Journal Thorac Cancer

Specialties Oncology
Pulmonary Medicine

Date 2019 Jun 28

PMID 31243894

Citations 12

Authors

Chunhai Li

Jie Wang

Jing-Bo Shao

Liang-Ming Zhu

Zhi-Gang Sun

Nan Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Microwave ablation (MWA) has recently become an established treatment option for topical therapy of lung cancer patients. In this study, we evaluated whether MWA combined with chemotherapy could improve progression-free survival (PFS) of patients with stage IV lung adenocarcinoma compared with chemotherapy alone.

Methods: A total of 49 patients were enrolled into the study; 21 patients accepted MWA therapy combined with chemotherapy, 28 patients accepted only chemotherapy. Enumeration data were analyzed using χ2 test or Fisher's exact probability test and univariate analysis was analyzed using Kaplan-Meier survival curves. Multivariate analysis was carried out with the Cox proportional hazard model.

Results: The treatment regimen was not correlated with clinical features of the patients, which included gender, age, smoking history, tumor site, tumor size and Eastern Cooperative Oncology Group (ECOG). The patients' 3-year overall survival (OS) was 12.5%, and median survival time was 19.3 months. The median PFS was 6.1 months and the 1-year PFS was 0.0%. The PFS was significantly associated with tumor size (P < 0.05), ECOG (P < 0.01) and treatment regimen (P < 0.01). The median time to local progression (TTLP) was 8.4 months and the 3-year TTLP was 2.0%. The TTLP was significantly associated with tumor size (P < 0.05) and treatment regimen (P < 0.01). Cox multivariate regression demonstrated that MWA combined with chemotherapy was the independent factor for both the PFS and TTLP.

Conclusion: MWA, as a topical treatment method, when combined with chemotherapy improved the PFS and TTLP of patients with stage IV lung adenocarcinoma.

Citing Articles

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References

Kong G, Anyarambhatla G, Petros W, Braun R, COLVIN O, Needham D . Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res. 2001; 60(24):6950-7. View

Schiller J, Harrington D, Belani C, Langer C, Sandler A, Krook J . Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002; 346(2):92-8. DOI: 10.1056/NEJMoa011954. View

Duisters C, Beurskens H, Nijsten S, Starmans M, Wanders S, Verschueren T . Palliative chest irradiation in sitting position in patients with bulky advanced lung cancer. Radiother Oncol. 2006; 79(3):285-7. DOI: 10.1016/j.radonc.2006.05.003. View

Pennathur A, Luketich J, Burton S, Abbas G, Heron D, Fernando H . Stereotactic radiosurgery for the treatment of lung neoplasm: initial experience. Ann Thorac Surg. 2007; 83(5):1820-4. DOI: 10.1016/j.athoracsur.2006.11.077. View

Abbas G, Schuchert M, Pennathur A, Gilbert S, Luketich J . Ablative treatments for lung tumors: radiofrequency ablation, stereotactic radiosurgery, and microwave ablation. Thorac Surg Clin. 2007; 17(2):261-71. DOI: 10.1016/j.thorsurg.2007.03.007. View

Molina J, Yang P, Cassivi S, Schild S, Adjei A . Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008; 83(5):584-94. PMC: 2718421. DOI: 10.4065/83.5.584. View

Scagliotti G, Parikh P, von Pawel J, Biesma B, Vansteenkiste J, Manegold C . Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol. 2008; 26(21):3543-51. DOI: 10.1200/JCO.2007.15.0375. View

Yu J, Liang P, Yu X, Liu F, Chen L, Wang Y . A comparison of microwave ablation and bipolar radiofrequency ablation both with an internally cooled probe: results in ex vivo and in vivo porcine livers. Eur J Radiol. 2010; 79(1):124-30. DOI: 10.1016/j.ejrad.2009.12.009. View

Auperin A, Le Pechoux C, Rolland E, Curran W, Furuse K, Fournel P . Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer. J Clin Oncol. 2010; 28(13):2181-90. DOI: 10.1200/JCO.2009.26.2543. View

10.

Jones C, Badger S, Ellis G . The role of microwave ablation in the management of hepatic colorectal metastases. Surgeon. 2011; 9(1):33-7. DOI: 10.1016/j.surge.2010.07.009. View

11.

Lee H, Jin G, Han Y, Chung G, Lee Y, Kwon K . Comparison of survival rate in primary non-small-cell lung cancer among elderly patients treated with radiofrequency ablation, surgery, or chemotherapy. Cardiovasc Intervent Radiol. 2011; 35(2):343-50. DOI: 10.1007/s00270-011-0194-y. View

12.

Zhang S, Zheng Y, Yu P, Yu F, Zhang Q, Lv Y . The combined treatment of CT-guided percutaneous 125I seed implantation and chemotherapy for non-small-cell lung cancer. J Cancer Res Clin Oncol. 2011; 137(12):1813-22. DOI: 10.1007/s00432-011-1048-3. View

13.

Crabtree T, Puri V, Timmerman R, Fernando H, Bradley J, Decker P . Treatment of stage I lung cancer in high-risk and inoperable patients: comparison of prospective clinical trials using stereotactic body radiotherapy (RTOG 0236), sublobar resection (ACOSOG Z4032), and radiofrequency ablation (ACOSOG Z4033). J Thorac Cardiovasc Surg. 2012; 145(3):692-9. DOI: 10.1016/j.jtcvs.2012.10.038. View

14.

Sun W, Song L, Ai T, Zhang Y, Gao Y, Cui J . Prognostic value of MET, cyclin D1 and MET gene copy number in non-small cell lung cancer. J Biomed Res. 2013; 27(3):220-30. PMC: 3664729. DOI: 10.7555/JBR.27.20130004. View

15.

Li X, Zhao M, Wang J, Fan W, Li W, Pan T . Percutaneous CT-guided radiofrequency ablation as supplemental therapy after systemic chemotherapy for selected advanced non-small cell lung cancers. AJR Am J Roentgenol. 2013; 201(6):1362-7. DOI: 10.2214/AJR.12.10511. View

16.

Yang X, Ye X, Zheng A, Huang G, Ni X, Wang J . Percutaneous microwave ablation of stage I medically inoperable non-small cell lung cancer: clinical evaluation of 47 cases. J Surg Oncol. 2014; 110(6):758-63. PMC: 4198430. DOI: 10.1002/jso.23701. View

17.

Li Y, Wei S, Wang J, Hong L, Cui L, Wang C . [Analysis of the factors associated with abnormal coagulation and prognosis  in patients with non-small cell lung cancer]. Zhongguo Fei Ai Za Zhi. 2014; 17(11):789-96. PMC: 6000357. DOI: 10.3779/j.issn.1009-3419.2014.11.04. View

18.

Wei Z, Ye X, Yang X, Huang G, Li W, Wang J . Microwave ablation plus chemotherapy improved progression-free survival of advanced non-small cell lung cancer compared to chemotherapy alone. Med Oncol. 2015; 32(2):464. DOI: 10.1007/s12032-014-0464-z. View

19.

Vogl T, Nour-Eldin N, Hammerstingl R, Panahi B, Naguib N . Microwave Ablation (MWA): Basics, Technique and Results in Primary and Metastatic Liver Neoplasms - Review Article. Rofo. 2017; 189(11):1055-1066. DOI: 10.1055/s-0043-117410. View

20.

Yang X, Ye X, Zhang L, Geng D, Du Z, Yu G . Microwave ablation for lung cancer patients with a single lung: Clinical evaluation of 11 cases. Thorac Cancer. 2018; 9(5):548-554. PMC: 5928380. DOI: 10.1111/1759-7714.12611. View