Acute Liver Failure Caused by the Transmission of Hepatitis B Virus from the Spouse After 38 Years of Marriage

Overview

Journal Intern Med

Specialty General Medicine

Date 2019 Jun 28

PMID 31243227

Citations 1

Authors

Naoto Sato

Shunji Watanabe

Kouichi Miura

Rie Goka

Naoki Morimoto

Yoshinari Takaoka

Hiroaki Nomoto

Mamiko Tsukui

Norio Isoda

Shigeo Nagashima

Masaharu Takahashi

Hiroaki Okamoto

Hironori Yamamoto

Affiliations

Soon will be listed here.

Abstract

A 65-year-old man presented with acute liver failure and grade IV coma caused by hepatitis B virus (HBV) infection in 2017. The patient died on day 12 from the disease onset. The HBV isolated from the patient was genotype/subgenotype B/B1 and had multiple genomic mutations. The patient's wife was hepatitis B surface antigen (HBsAg)-positive when she delivered her first daughter in 1979. The HBV isolates of the patient and the wife shared 100% similarity over the entire genome. Because the patient's HBsAg value had been negative one year earlier, we considered the source of HBV transmission to be his wife.

Citing Articles

Analysis of HBV Genomes Integrated into the Genomes of Human Hepatoma PLC/PRF/5 Cells by HBV Sequence Capture-Based Next-Generation Sequencing.

Ishii T, Tamura A, Shibata T, Kuroda K, Kanda T, Sugiyama M Genes (Basel). 2020; 11(6).

PMID: 32570699 PMC: 7348787. DOI: 10.3390/genes11060661.

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