Molecular Markers Relevant to Myocardial Injury Following Dental Extraction in Patients with or Without Coronary Artery Disease

Overview

Journal BDJ Open

Specialty Dentistry

Date 2019 Jun 27

PMID 31240112

Citations 6

Authors

K M Habbab

F DAiuto

M A Habbab

S R Porter

Affiliations

Soon will be listed here.

Abstract

Objectives: The aim of this study was to characterize biological changes following dental extractions in patients with or without coronary artery disease (CAD).

Materials And Methods: Forty-five patients (36 males and 9 females) referred for dental extraction underwent treatment and provided blood samples before, immediately after, and 24 h after the procedure. A broad array of biomarkers was employed to assess myocardial injury (highly sensitive troponin T, hs-TnT), bacterial burden (LPS endotoxin activity), and systemic inflammation (CRP, fibrinogen, IFN-γ, IL-1β, IL-6, IL-8, IL-10, IL-12, and TNF-α).

Results: Dental extraction in patients with or without CAD was associated with rises in hs-TnT ( = 0.013), hs-CRP ( < 0.001), fibrinogen ( = 0.005), endotoxin activity ( < 0.001), IFN-γ ( < 0.001), IL-6 ( < 0.001), IL-8 ( = 0.011), and IL-12 ( < 0.001) at 24 h compared with immediately post procedure. Changes in systemic inflammation and endotoxin activity were more evident in those with hs-TnT rise.

Conclusions: Simple dental extractions may cause mild increase in hs-TnT, indicating minor myocardial injury in both patients with or without CAD. Acute systemic inflammation and endotoxemia could represent a possible link between invasive dental treatment and increased risk of acute cardiovascular events. These findings indicate that invasive dental treatment (as simple as a single dental extraction) may impact negatively on clinical outcomes in dental patients, especially those with CAD.

Citing Articles

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Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia.

Pussinen P, Kopra E, Pietiainen M, Lehto M, Zaric S, Paju S Periodontol 2000. 2022; 89(1):19-40.

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Invasive dental treatment and acute vascular events: A systematic review and meta-analysis.

Luthra S, Orlandi M, Leira Y, Bokre D, Marletta D, Rotundo R J Clin Periodontol. 2022; 49(5):467-479.

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Severe Periodontitis and Biomarkers of Bacterial Burden. Results From a Case-Control and Intervention Clinical Trial.

Leira Y, Fragkiskos D, Orlandi M, Suvan J, Nibali L, Tonetti M Front Oral Health. 2022; 2:615579.

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