HLA-VBSeq V2: Improved HLA Calling Accuracy with Full-length Japanese Class-I Panel

Overview

Journal Hum Genome Var

Date 2019 Jun 27

PMID 31240105

Citations 6

Authors

Yen-Yen Wang

Takahiro Mimori

Seik-Soon Khor

Olivier Gervais

Yosuke Kawai

Yuki Hitomi

Katsushi Tokunaga

Masao Nagasaki

Affiliations

Soon will be listed here.

Abstract

HLA-VBSeq is an HLA calling tool developed to infer the most likely HLA types from high-throughput sequencing data. However, there is still room for improvement in specific genetic groups because of the diversity of HLA alleles in human populations. Here, we present HLA-VBSeq v2, a software application that makes use of a new Japanese HLA reference panel to enhance calling accuracy for Japanese HLA class-I genes. Our analysis showed significant improvements in calling accuracy in all HLA regions, with prediction accuracies achieving over 99.0, 97.8, and 99.8% in HLA-A, B and C, respectively.

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