Cells Involved in Urethral Tissue Engineering: Systematic Review

Overview

Journal Cell Transplant

Specialties Cell Biology
General Surgery

Date 2019 Jun 26

PMID 31237144

Citations 10

Authors

Martina Culenova

Stanislav Ziaran

Lubos Danisovic

Affiliations

Soon will be listed here.

Abstract

The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The occurrence of this pathology is more common in men and thus are previous research has been mainly oriented on male urethra reconstruction. However, commonly used surgical techniques show unsatisfactory results because of complications. The new and progressively developing field of tissue engineering offers promising solutions, which could be applied in the urethral regeneration of both men´s and women´s urethras. The presented systematic review article offers an overview of the cells that have been used in urethral tissue engineering so far. Urine-derived stem cells show a great perspective in respect to urethral tissue engineering. They can be easily harvested and are a promising autologous cell source for the needs of tissue engineering techniques. The presented review also shows the importance of mechanical stimuli application on maturating tissue. Sufficient vascularization and elimination of stricture formation present the biggest challenges not only in customary surgical management but also in tissue-engineering approaches.

Citing Articles

Tissue Engineering for Penile Reconstruction.

Elia E, Caneparo C, McMartin C, Chabaud S, Bolduc S Bioengineering (Basel). 2024; 11(3).

PMID: 38534504 PMC: 10967839. DOI: 10.3390/bioengineering11030230.

Urine-derived stem cells: Promising advancements and applications in regenerative medicine and beyond.

Sun Y, Zhao H, Yang S, Wang G, Zhu L, Sun C Heliyon. 2024; 10(6):e27306.

PMID: 38509987 PMC: 10951541. DOI: 10.1016/j.heliyon.2024.e27306.

Urine-derived stem cells in neurological diseases: current state-of-the-art and future directions.

Cavaleiro C, Afonso G, Oliveira P, Valero J, Mota S, Ferreiro E Front Mol Neurosci. 2023; 16:1229728.

PMID: 37965041 PMC: 10642248. DOI: 10.3389/fnmol.2023.1229728.

Biological Macromolecule-Based Scaffolds for Urethra Reconstruction.

Farzamfar S, Richer M, Rahmani M, Naji M, Aleahmad M, Chabaud S Biomolecules. 2023; 13(8).

PMID: 37627232 PMC: 10452429. DOI: 10.3390/biom13081167.

Prospects and Challenges of Electrospun Cell and Drug Delivery Vehicles to Correct Urethral Stricture.

Farzamfar S, Elia E, Chabaud S, Naji M, Bolduc S Int J Mol Sci. 2022; 23(18).

PMID: 36142432 PMC: 9502833. DOI: 10.3390/ijms231810519.

References

Tayhan S, Tezcan Keles G, Topcu I, Mir E, Deliloglu Gurhan S . Isolation and cultivation of human urine-derived cells: an alternative stem cell source. Turk J Urol. 2017; 43(3):345-349. PMC: 5562256. DOI: 10.5152/tud.2017.93797. View

Guan Y, Ou L, Hu G, Wang H, Xu Y, Chen J . Tissue engineering of urethra using human vascular endothelial growth factor gene-modified bladder urothelial cells. Artif Organs. 2007; 32(2):91-9. DOI: 10.1111/j.1525-1594.2007.00502.x. View

Santucci R, Joyce G, Wise M . Male urethral stricture disease. J Urol. 2007; 177(5):1667-74. DOI: 10.1016/j.juro.2007.01.041. View

Jiang S, Xu Z, Zhao Y, Yan L, Zhou Z, Gu G . Urethral Reconstruction Using Mesothelial Cell-Seeded Autogenous Granulation Tissue Tube: An Experimental Study in Male Rabbits. Biomed Res Int. 2017; 2017:1850256. PMC: 5350385. DOI: 10.1155/2017/1850256. View

Zhou S, Yang R, Zou Q, Zhang K, Yin T, Zhao W . Fabrication of Tissue-Engineered Bionic Urethra Using Cell Sheet Technology and Labeling By Ultrasmall Superparamagnetic Iron Oxide for Full-Thickness Urethral Reconstruction. Theranostics. 2017; 7(9):2509-2523. PMC: 5525753. DOI: 10.7150/thno.18833. View

Singh A, Bivalacqua T, Sopko N . Urinary Tissue Engineering: Challenges and Opportunities. Sex Med Rev. 2017; 6(1):35-44. DOI: 10.1016/j.sxmr.2017.08.004. View

Qin D, Long T, Deng J, Zhang Y . Urine-derived stem cells for potential use in bladder repair. Stem Cell Res Ther. 2014; 5(3):69. PMC: 4055102. DOI: 10.1186/scrt458. View

Barbagli G, Balo S, Montorsi F, Sansalone S, Lazzeri M . History and evolution of the use of oral mucosa for urethral reconstruction. Asian J Urol. 2017; 4(2):96-101. PMC: 5717976. DOI: 10.1016/j.ajur.2016.05.006. View

Fu Q, Deng C, Zhao R, Wang Y, Cao Y . The effect of mechanical extension stimulation combined with epithelial cell sorting on outcomes of implanted tissue-engineered muscular urethras. Biomaterials. 2013; 35(1):105-12. DOI: 10.1016/j.biomaterials.2013.09.067. View

10.

Lumen N, Oosterlinck W, Hoebeke P . Urethral reconstruction using buccal mucosa or penile skin grafts: systematic review and meta-analysis. Urol Int. 2012; 89(4):387-94. DOI: 10.1159/000341138. View

11.

Hoag N, Chee J . Surgical management of female urethral strictures. Transl Androl Urol. 2017; 6(Suppl 2):S76-S80. PMC: 5522798. DOI: 10.21037/tau.2017.01.20. View

12.

Nath N, Saraswat S, Jain S, Koteshwar S . Inhibition of proliferation and migration of stricture fibroblasts by epithelial cell-conditioned media. Indian J Urol. 2015; 31(2):111-5. PMC: 4397546. DOI: 10.4103/0970-1591.152809. View

13.

Heller M, Frerick-Ochs E, Bauer H, Schiegnitz E, Flesch D, Brieger J . Tissue engineered pre-vascularized buccal mucosa equivalents utilizing a primary triculture of epithelial cells, endothelial cells and fibroblasts. Biomaterials. 2015; 77:207-15. DOI: 10.1016/j.biomaterials.2015.10.073. View

14.

Cattan V, Bernard G, Rousseau A, Bouhout S, Chabaud S, Auger F . Mechanical stimuli-induced urothelial differentiation in a human tissue-engineered tubular genitourinary graft. Eur Urol. 2011; 60(6):1291-8. DOI: 10.1016/j.eururo.2011.05.051. View

15.

Li C, Xu Y, Liu Z, Li H . Urethral reconstruction with tissue engineering and RNA interference techniques in rabbits. Urology. 2013; 81(5):1075-80. DOI: 10.1016/j.urology.2013.01.041. View

16.

Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D . Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4):315-7. DOI: 10.1080/14653240600855905. View

17.

Gallegos M, Santucci R . Advances in urethral stricture management. F1000Res. 2017; 5:2913. PMC: 5225410. DOI: 10.12688/f1000research.9741.1. View

18.

Smith 3rd T . Current management of urethral stricture disease. Indian J Urol. 2016; 32(1):27-33. PMC: 4756546. DOI: 10.4103/0970-1591.173108. View

19.

Yang H, Chen B, Deng J, Zhuang G, Wu S, Liu G . Characterization of rabbit urine-derived stem cells for potential application in lower urinary tract tissue regeneration. Cell Tissue Res. 2018; 374(2):303-315. DOI: 10.1007/s00441-018-2885-z. View

20.

Rogovaya O, Fayzulin A, Vasiliev A, Kononov A, Terskikh V . Reconstruction of rabbit urethral epithelium with skin keratinocytes. Acta Naturae. 2015; 7(1):70-7. PMC: 4410397. View