Lambert-Eaton Myasthenic Syndrome and Merkel Cell Carcinoma

Overview

Journal Cutis

Specialty Dermatology

Date 2019 Jun 25

PMID 31233589

Citations 7

Authors

Nam D Nguyen

Daniel B Simmons

Adrian R Bersabe

Thomas M Duginski

John H Sladky

Douglas Walton

Micah Will

John S Renshaw

Affiliations

Soon will be listed here.

Abstract

Lambert-Eaton myasthenic syndrome (LEMS) is an antibody-mediated disorder of the neuromuscular junction that is most commonly diagnosed in association with small cell lung carcinoma (SCLC). Small cell lung carcinoma is histologically similar to the aggressive cutaneous neuroendocrine malignancy Merkel cell carcinoma (MCC). We provide a full report and longitudinal clinical follow-up of a case of LEMS occurring with MCC. We also review the literature on paraneoplastic syndromes associated with MCC and other nonpulmonary small cell carcinomas.

Citing Articles

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Combined treatment with radiotherapy, chemotherapy and avelumab results in regression of metastatic Merkel cell carcinoma and improvement of associated Lambert-Eaton myasthenic syndrome: A case report.

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