Natural History of Radiographic First Metatarsophalangeal Joint Osteoarthritis: A Nineteen-Year Population-Based Cohort Study

Overview

Journal Arthritis Care Res (Hoboken)

Specialty Rheumatology

Date 2019 Jun 25

PMID 31233277

Citations 4

Authors

Catherine Bowen

Lucy Gates

Peter McQueen

Maxine Daniels

Antonella Delmestri

Wendy Drechsler

David Stephensen

Michael Doherty

Nigel Arden

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the long-term prevalence, natural history, progression, and incidence of radiographic first metatarsophalangeal (MTP) joint osteoarthritis (OA).

Methods: A longitudinal cohort design was used in which radiographic OA at the first MTP joint was investigated in participants from the Chingford 1,000 Women Study at year 6 (1995) and year 23 (2013-2015). Radiographic features of osteophytes (OPs) and/or joint space narrowing (JSN) at the first MTP joint were scored according to a validated foot atlas. Natural history was determined by the change in prevalence, incidence, progression, and worsening of OA in the first MTP joint.

Results: Complete case-matched foot radiographic data were available for 193 of the women currently enrolled in the study (mean ± SD age 75.7 ± 5.2 years [range 69-90 years]). At the level of the first MTP joint, prevalence of OA at year 6 was 21.76% in the left and 24.35% in the right; at year 23, it was 23.83% in the left and 32.64% in the right. Over the 19-year period, 13.5% of the women developed incident OA in the right first MTP joint and 8.3% in the left. Both progression and worsening of OA were more evident for OPs and in the right first MTP joints.

Conclusion: In this study of the natural history of radiographic first MTP joint OA, which to our knowledge is the longest study to date, the prevalence and incidence of first MTP joint OA increased over a 19-year period. Progression and/or worsening of OA at the first MTP joint over time appears to be driven by OP development rather than JSN, which suggests a biomechanical cause.

Citing Articles

A multi-professional survey of UK practice in the use of intra-articular corticosteroid injection for symptomatic first metatarsophalangeal joint osteoarthritis.

Backhouse M, Halstead J, Roddy E, Dhukaram V, Chapman A, Arnold S J Foot Ankle Res. 2023; 16(1):71.

PMID: 37845758 PMC: 10580568. DOI: 10.1186/s13047-023-00672-6.

International Foot and Ankle Osteoarthritis Consortium review and research agenda for diagnosis, epidemiology, burden, outcome assessment and treatment.

Arnold J, Bowen C, Chapman L, Gates L, Golightly Y, Halstead J Osteoarthritis Cartilage. 2022; 30(7):945-955.

PMID: 35176480 PMC: 10464637. DOI: 10.1016/j.joca.2022.02.603.

Identifying Long-Term Trajectories of Foot Pain Severity and Potential Prognostic Factors: A Population-Based Cohort Study.

Marshall M, Blagojevic-Bucknall M, Rathod-Mistry T, Thomas M, Edwards J, Peat G Arthritis Care Res (Hoboken). 2021; 75(5):1123-1131.

PMID: 34806345 PMC: 10952181. DOI: 10.1002/acr.24823.

Lifetime occupation is not associated with radiographic osteoarthritis of the first metatarsophalangeal joint in a cohort study of UK women.

Cherry L, Gates L, Arden N, Bowen C J Foot Ankle Res. 2020; 13(1):61.

PMID: 33004072 PMC: 7528246. DOI: 10.1186/s13047-020-00429-5.

References

Downes T, Chesterton L, Whittle R, Roddy E, Menz H, Marshall M . Symptomatic Course of Foot Osteoarthritis Phenotypes: An 18-Month Prospective Analysis of Community-Dwelling Older Adults. Arthritis Care Res (Hoboken). 2017; 70(7):1107-1112. PMC: 6067068. DOI: 10.1002/acr.23502. View

Hart D, Mootoosamy I, Doyle D, Spector T . The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study. Ann Rheum Dis. 1994; 53(3):158-62. PMC: 1005278. DOI: 10.1136/ard.53.3.158. View

Roddy E, Myers H, Thomas M, Marshall M, DCruz D, Menz H . The clinical assessment study of the foot (CASF): study protocol for a prospective observational study of foot pain and foot osteoarthritis in the general population. J Foot Ankle Res. 2011; 4:22. PMC: 3180294. DOI: 10.1186/1757-1146-4-22. View

Leyland K, Hart D, Javaid M, Judge A, Kiran A, Soni A . The natural history of radiographic knee osteoarthritis: a fourteen-year population-based cohort study. Arthritis Rheum. 2012; 64(7):2243-51. DOI: 10.1002/art.34415. View

Neame R, Zhang W, Deighton C, Doherty M, Doherty S, Lanyon P . Distribution of radiographic osteoarthritis between the right and left hands, hips, and knees. Arthritis Rheum. 2004; 50(5):1487-94. DOI: 10.1002/art.20162. View

Trivedi B, Marshall M, Belcher J, Roddy E . A systematic review of radiographic definitions of foot osteoarthritis in population-based studies. Osteoarthritis Cartilage. 2010; 18(8):1027-35. DOI: 10.1016/j.joca.2010.05.005. View

Gates L, Arden N, Hannan M, Roddy E, Gill T, Hill C . Prevalence of Foot Pain Across an International Consortium of Population-Based Cohorts. Arthritis Care Res (Hoboken). 2018; 71(5):661-670. PMC: 6483849. DOI: 10.1002/acr.23829. View

Hart D, Spector T . The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol. 1993; 20(2):331-5. View

Mahiquez M, Wilder F, Stephens H . Positive hindfoot valgus and osteoarthritis of the first metatarsophalangeal joint. Foot Ankle Int. 2007; 27(12):1055-9. DOI: 10.1177/107110070602701210. View

10.

Awale A, Hagedorn T, Dufour A, Menz H, Casey V, Hannan M . Foot Function, Foot Pain, and Falls in Older Adults: The Framingham Foot Study. Gerontology. 2017; 63(4):318-324. PMC: 5501294. DOI: 10.1159/000475710. View

11.

Kopec J, Sayre E, Schwartz T, Renner J, Helmick C, Badley E . Occurrence of radiographic osteoarthritis of the knee and hip among African Americans and whites: a population-based prospective cohort study. Arthritis Care Res (Hoboken). 2013; 65(6):928-35. PMC: 4206562. DOI: 10.1002/acr.21924. View

12.

Golightly Y, Hannan M, Shi X, Helmick C, Renner J, Jordan J . Association of foot symptoms with self-reported and performance-based measures of physical function: The Johnston County osteoarthritis project. Arthritis Care Res (Hoboken). 2011; 63(5):654-9. PMC: 3092015. DOI: 10.1002/acr.20432. View

13.

Harris P, Taylor R, Thielke R, Payne J, Gonzalez N, Conde J . Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2008; 42(2):377-81. PMC: 2700030. DOI: 10.1016/j.jbi.2008.08.010. View

14.

Roddy E, Menz H . Foot osteoarthritis: latest evidence and developments. Ther Adv Musculoskelet Dis. 2018; 10(4):91-103. PMC: 5871064. DOI: 10.1177/1759720X17753337. View

15.

Garrow A, Silman A, Macfarlane G . The Cheshire Foot Pain and Disability Survey: a population survey assessing prevalence and associations. Pain. 2004; 110(1-2):378-84. DOI: 10.1016/j.pain.2004.04.019. View

16.

Hill C, Gill T, Menz H, Taylor A . Prevalence and correlates of foot pain in a population-based study: the North West Adelaide health study. J Foot Ankle Res. 2008; 1(1):2. PMC: 2547889. DOI: 10.1186/1757-1146-1-2. View

17.

Roddy E, Thomas M, Marshall M, Rathod T, Myers H, Menz H . The population prevalence of symptomatic radiographic foot osteoarthritis in community-dwelling older adults: cross-sectional findings from the clinical assessment study of the foot. Ann Rheum Dis. 2013; 74(1):156-63. PMC: 4283621. DOI: 10.1136/annrheumdis-2013-203804. View

18.

Dufour A, Broe K, Nguyen U, Gagnon D, Hillstrom H, Walker A . Foot pain: is current or past shoewear a factor?. Arthritis Rheum. 2009; 61(10):1352-8. PMC: 2761974. DOI: 10.1002/art.24733. View

19.

Kalichman L, Hernandez-Molina G . Midfoot and forefoot osteoarthritis. Foot (Edinb). 2014; 24(3):128-34. DOI: 10.1016/j.foot.2014.05.002. View

20.

Kellgren J, Lawrence J . Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16(4):494-502. PMC: 1006995. DOI: 10.1136/ard.16.4.494. View