Recent Advances on Polymeric Beads or Hydrogels As Embolization Agents for Improved Transcatheter Arterial Chemoembolization (TACE)

Overview

Journal Front Chem

Specialty Chemistry

Date 2019 Jun 25

PMID 31231636

Citations 17

Authors

Yun-Ping Chen

Jiang-Ling Zhang

Yanhong Zou

Yun-Long Wu

Affiliations

Soon will be listed here.

Abstract

Transcatheter arterial chemoembolization (TACE), aiming to block the hepatic artery for inhibiting tumor blood supply, became a popular therapy for hepatocellular carcinoma (HCC) patients. Traditional TACE formulation of anticancer drug emulsion in ethiodized oil (i.e., Lipiodol) and gelatin sponge (i.e., Gelfoam) had drawbacks on patient tolerance and resulted in undesired systemic toxicity, which were both significantly improved by polymeric beads, microparticles, or hydrogels by taking advantage of the elegant design of biocompatible or biodegradable polymers, especially amphiphilic polymers or polymers with both hydrophilic and hydrophobic chains, which could self-assemble into proposed microspheres or hydrogels. In this review, we aimed to summarize recent advances on polymeric embolization beads or hydrogels as TACE agents, with emphasis on their material basis of polymer architectures, which are important but have not yet been comprehensively summarized.

Citing Articles

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Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model.

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Bioengineered Ionic Liquid for Catheter-Directed Tissue Ablation, Drug Delivery, and Embolization.

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