IL-1 Family Members in Cancer; Two Sides to Every Story

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 Jun 25

PMID 31231372

Citations 138

Authors

Kevin J Baker

Aileen Houston

Elizabeth Brint

Affiliations

Soon will be listed here.

Abstract

The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti-inflammatory activity (IL-37, IL-38). These cytokines are known to play a key role in modulating both the innate and adaptive immunes response, with dysregulation linked to a variety of autoimmune and inflammatory diseases. Given the increasing appreciation of the link between inflammation and cancer, the role of several members of this family in the pathogenesis of cancer has been extensively investigated. In this review, we highlight both the pro- and anti-tumorigenic effects identified for almost all members of this family, and explore potential underlying mechanisms accounting for these divergent effects. Such dual functions need to be carefully assessed when developing therapeutic intervention strategies targeting these cytokines in cancer.

Citing Articles

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