Characterization of the Receptor for IgM Present on Human B Lymphocytes

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1979 Mar 1

PMID 312263

Citations 4

Authors

G F Burns

J C Cawley

C R Barker

Affiliations

Soon will be listed here.

Abstract

The presence of a receptor for the Fc of IgM (muFcR) was demonstrated on the pathological B cells of all of sixteen patients with hairy-cell leukaemia and most, but not all, of twenty-four cases of chronic lymphocytic leukaemia, by a rosette method employing ox erythrocytes sensitized with purified IgM (EAm). This muFcR was also demonstrated on a small population of normal human mononuclear cells from peripheral blood. Pathological B cells with this receptor (Bm) simultaneously expressed a different and distinct receptor for the Fc of IgG, and were detectable without preincubation in medium containing foetal calf serum (FCS). The muFcR on B cells was blocked by Fc5mu and IgM, but not by F(ab')2mu fragments, or by IgG, whether monomeric or aggregated. Monomeric IgM and IgM bound to its antigen blocked much more effectively than pentameric IgM. B cells also possessed surface immunoglobulin and the Ia-like P29, 34 antigen, and an antiserum to this antigen blocked the muFcR. The muFcR on B cells differs in a number of ways from the muFcR reported on T cells, and these differential characteristics are discussed in some detail. The muFcR was rapidly shed and resynthesized when washed Bm cells were maintained in medium not containing FCS and the general importance of this phenomenon in any study of muFcR is considered. It is suggested that Bm cells are memory cells and that the muFcR plays a part in the immune response.

Citing Articles

Role of the IgM Fc Receptor in Immunity and Tolerance.

Liu J, Wang Y, Xiong E, Hong R, Lu Q, Ohno H Front Immunol. 2019; 10:529.

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Kubagawa H, Oka S, Kubagawa Y, Torii I, Takayama E, Kang D J Clin Immunol. 2014; 34 Suppl 1:S35-45.

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Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (FcμR) in patients with chronic lymphocytic leukemia.

Li F, Kubagawa Y, McCollum M, Wilson L, Motohashi T, Bertoli L Blood. 2011; 118(18):4902-9.

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Biochemical nature of an Fc mu receptor on human B-lineage cells.

Ohno T, Kubagawa H, Sanders S, Cooper M J Exp Med. 1990; 172(4):1165-75.

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