Recent Progress in the Role of Autophagy in Neurological Diseases

Overview

Journal Cell Stress

Date 2019 Jun 22

PMID 31225510

Citations 26

Authors

Tian Meng

Shiyin Lin

Haixia Zhuang

Haofeng Huang

Zhengjie He

Yongquan Hu

Qing Gong

Du Feng

Affiliations

Soon will be listed here.

Abstract

Autophagy (here refers to macroautophagy) is a catabolic pathway by which large protein aggregates and damaged organelles are first sequestered into a double-membraned structure called autophago-some and then delivered to lysosome for destruction. Recently, tremen-dous progress has been made to elucidate the molecular mechanism and functions of this essential cellular metabolic process. In addition to being either a rubbish clearing system or a cellular surviving program in response to different stresses, autophagy plays important roles in a large number of pathophysiological conditions, such as cancer, diabetes, and especially neurodegenerative disorders. Here we review recent progress in the role of autophagy in neurological diseases and discuss how dysregulation of autophagy initiation, autophagosome formation, maturation, and/or au-tophagosome-lysosomal fusion step contributes to the pathogenesis of these disorders in the nervous system.

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