» Articles » PMID: 31222744

Trigeminal Neuralgia and Charcot-Marie-Tooth Disease: An Intriguing Association. Lessons From a Large Family Case Report and Review of Literature

Overview
Journal Headache
Publisher Wiley
Specialties Neurology
Psychiatry
Date 2019 Jun 22
PMID 31222744
Citations 4
Authors
Affiliations
Soon will be listed here.
Abstract

Background: The association of TN in CMT patients has previously been reported in a few cases. The pathophysiological link can be detailed with recent use of genetic analysis in CMT.

Methods: We report a large family including 7 members affected by CMT, 4 of whom also presented with TN. We then performed a literature review of literature by search of Pubmed from 1950 to September 2018, using the search terms "trigeminal neuralgia" and "Charcot-Marie-Tooth" and the references of relevant articles.

Results: Overall, we found 29 previously published TN cases in 12 CMT families. Among them, only 7 families (69%) included several affected members, suggesting that not all mutations involved in CMT predispose to TN. TN in this context seems to present with specific characteristics, including earlier age of onset, bilateral presentation, and poor tolerance to preventive treatments with gait disturbance exacerbated by the underlying neuropathy.

Conclusion: This report of familial TN in CMT with identified MPZ mutation highlighted specific characteristics of this association. Considered as a rare association in the literature, it may be underestimated and the clinician should be aware of its specific pattern, including earlier age of onset, bilateral presentation, and poor tolerance to preventive treatments.

Citing Articles

Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia.

Lafta M, Rukh G, Abu Hamdeh S, Molero Y, Sokolov A, Rostami E J Mol Neurosci. 2024; 74(4):91.

PMID: 39361088 PMC: 11449953. DOI: 10.1007/s12031-024-02263-x.


Trigeminal neuralgia.

Ashina S, Robertson C, Srikiatkhachorn A, Stefano G, Donnet A, Hodaie M Nat Rev Dis Primers. 2024; 10(1):39.

PMID: 38816415 DOI: 10.1038/s41572-024-00523-z.


MARS1 mutations linked to familial trigeminal neuralgia via the integrated stress response.

Wang A, Song Z, Zhang X, Xiao L, Feng Y, Qi C J Headache Pain. 2023; 24(1):4.

PMID: 36641423 PMC: 9840295. DOI: 10.1186/s10194-022-01537-2.


Trigeminal neuralgia and genetics: A systematic review.

Mannerak M, Lashkarivand A, Eide P Mol Pain. 2021; 17:17448069211016139.

PMID: 34000891 PMC: 8135221. DOI: 10.1177/17448069211016139.