Spinal Metastases of Supratentorial Glioblastoma with Primitive Neuronal Component

Overview

Journal World Neurosurg X

Date 2019 Jun 21

PMID 31218293

Citations 5

Authors

Kathrin Vollmer

Georgios Pantazis

Javier Anon

Ulrich Roelcke

Lucia Schwyzer

Affiliations

Soon will be listed here.

Abstract

Background: Glioblastoma multiforme with a primitive neuronal component is a rare entity, with few cases reported in the literature.

Case Description: A patient who had a supratentorial glioblastoma multiforme with a primitive neuronal component developed spinal metastasis during the disease course. With his history of leukemia during childhood, he was likely exposed to therapeutic ionizing brain radiation, which could have increased the risk of developing brain cancer in adulthood.

Conclusions: The range of incidence rates of dissemination in the literature is 2%-4%, typically in cases of cerebellar glioblastoma multiforme, but as high as 25% in autopsy series. Our case highlights several other topics in the literature, such as immunohistochemical patterns that differ between the primary tumor and spinal metastases and dissemination locations, typically leptomeningeal or ventricular invasion.

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