HSDL2 Promotes Bladder Cancer Growth and

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2019 Jun 21

PMID 31217732

Citations 7

Authors

Ling-Hua Jia

Mei-Di Hu

Yuan Liu

Xing Xiong

Wei-Jia Wang

Jin-Gen Wang

Qiu-Gen Li

Affiliations

Soon will be listed here.

Abstract

Bladder cancer is a common malignant urinary tumor, and patients with bladder cancer have poor prognosis. Abnormal lipid metabolism in peroxisomes is involved in tumor progression. Hydroxysteroid dehydrogenase-like 2 (HSDL2) localized in peroxisomes regulates fatty acid synthesis. In the present study, we reported that HSDL2 was upregulated in two human bladder cancer cell lines 5637 and T24 compared to normal human urothelial cells. Furthermore, lentiviral-mediated HSDL2 knockdown inhibited the proliferation and colony formation while promoted the apoptosis of human bladder cancer T24 cells . In nude mice HSDL2 knockdown inhibited the growth of T24 derived xenografts . In conclusion, our results suggest that HSDL2 plays an oncogenic role in bladder cancer and might serve as a potential target for bladder cancer therapy.

Citing Articles

HSDL2 links nutritional cues to bile acid and cholesterol homeostasis.

Samson N, Bosoi C, Roy C, Turcotte L, Tribouillard L, Mouchiroud M Sci Adv. 2024; 10(22):eadk9681.

PMID: 38820148 PMC: 11141617. DOI: 10.1126/sciadv.adk9681.

HSDL2 knockdown promotes the progression of cholangiocarcinoma by inhibiting ferroptosis through the P53/SLC7A11 axis.

Ma S, Ma Y, Qi F, Lei J, Chen F, Sun W World J Surg Oncol. 2023; 21(1):293.

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[HSDL2 overexpression promotes rectal cancer progression by regulating cancer cell cycle and promoting cell proliferation].

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MiR-26a-5p regulates proliferation, apoptosis, migration and invasion via inhibiting hydroxysteroid dehydrogenase like-2 in cervical cancer cell.

Li M, Xiao Y, Liu M, Ning Q, Xiang Z, Zheng X BMC Cancer. 2022; 22(1):876.

PMID: 35948893 PMC: 9367141. DOI: 10.1186/s12885-022-09970-x.

Lipid metabolism regulator human hydroxysteroid dehydrogenase-like 2 (HSDL2) modulates cervical cancer cell proliferation and metastasis.

Yang Y, Han A, Wang X, Yin X, Cui M, Lin Z J Cell Mol Med. 2021; 25(10):4846-4859.

PMID: 33738911 PMC: 8107089. DOI: 10.1111/jcmm.16461.

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