Effects of Corynebacterium Parvum and BCG Therapy on Immune Parameters in Patients with Disseminated Melanoma. A Sequential Study over 28 Days. II. Changes in Non-specific (NK, K and T Cell) Lymphocytoxicity and Delayed Hypersensitivity Skin...

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1979 Feb 1

PMID 312169

Citations 5

Authors

N Thatcher

R Swindell

D Crowther

Affiliations

Soon will be listed here.

Abstract

C. parvum and BCG produced significant changes in NK, K and T cell lymphocytotoxicity using a Chang liver target cell. A consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. This was particularly marked for C. parvum and 'K' cell activity. Skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. The importance of using lymphocyte concentration-cytotoxicity titration curves and the linearization of such curves is discussed. An immunotherapy schedule with 3 weekly immunization intervals is proposed as the optimum schedule in patients receiving C. parvum at a dose of 2.0 mg/m2 i.v.

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Decreased monocyte antibody-dependent cell-mediated toxicity in stage I-II malignant melanoma. Augmentation by subcutaneous Corynebacterium parvum.

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Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity....

Thatcher N, Swindell R, Crowther D Clin Exp Immunol. 1979; 36(2):227-36.

PMID: 314367 PMC: 1537734.

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