Assessment of Vaccine-Induced Immunity Against Canine Visceral Leishmaniasis

Overview

Journal Front Vet Sci

Specialty Veterinary Medicine

Date 2019 Jun 20

PMID 31214607

Citations 13

Authors

Javier Moreno

Affiliations

Soon will be listed here.

Abstract

Canine visceral leishmaniasis is an increasingly important public health problem. Dogs infected by are the main domestic reservoir of the parasite and play a key role in its transmission to humans. Recent findings have helped in the development of novel diagnostic methods, and of control measures such as vaccines, some of which are already commercially available. However, quantitative procedures should be followed to confirm whether these vaccines elicit a cell-mediated immune response. The present work describes the need for this evaluation, and the techniques available for confirming this type of immune response.

Citing Articles

Advances in Vaccines: Current Development and Future Prospects.

Ayala A, Llanes A, Lleonart R, Restrepo C Pathogens. 2024; 13(9).

PMID: 39339003 PMC: 11435054. DOI: 10.3390/pathogens13090812.

Next-Generation Leishmanization: Revisiting Molecular Targets for Selecting Genetically Engineered Live-Attenuated .

Moreira P, Nogueira P, Monte-Neto R Microorganisms. 2023; 11(4).

PMID: 37110466 PMC: 10145799. DOI: 10.3390/microorganisms11041043.

Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster.

Gonzalez M, Goncalves A, Ottino J, Leite J, Resende L, Melo-Junior O Vaccines (Basel). 2023; 11(1).

PMID: 36679956 PMC: 9863486. DOI: 10.3390/vaccines11010111.

Canine Leishmaniasis: Update on Epidemiology, Diagnosis, Treatment, and Prevention.

Morales-Yuste M, Martin-Sanchez J, Corpas-Lopez V Vet Sci. 2022; 9(8).

PMID: 36006301 PMC: 9416075. DOI: 10.3390/vetsci9080387.

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis.

Segarra S Microorganisms. 2021; 9(12).

PMID: 34946204 PMC: 8703464. DOI: 10.3390/microorganisms9122601.

References

Moreno J, Nieto J, Chamizo C, Gonzalez F, Blanco F, Barker D . The immune response and PBMC subsets in canine visceral leishmaniasis before, and after, chemotherapy. Vet Immunol Immunopathol. 1999; 71(3-4):181-95. DOI: 10.1016/s0165-2427(99)00096-3. View

Solano-Gallego L, Llull J, Ramos G, Riera C, Arboix M, Alberola J . The Ibizian hound presents a predominantly cellular immune response against natural Leishmania infection. Vet Parasitol. 2000; 90(1-2):37-45. DOI: 10.1016/s0304-4017(00)00223-5. View

Solano-Gallego L, Morell P, Arboix M, Alberola J, Ferrer L . Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology. J Clin Microbiol. 2001; 39(2):560-3. PMC: 87775. DOI: 10.1128/JCM.39.2.560-563.2001. View

Quinnell R, Courtenay O, Davidson S, Garcez L, Lambson B, Ramos P . Detection of Leishmania infantum by PCR, serology and cellular immune response in a cohort study of Brazilian dogs. Parasitology. 2001; 122(Pt 3):253-61. DOI: 10.1017/s0031182001007363. View

Handman E . Leishmaniasis: current status of vaccine development. Clin Microbiol Rev. 2001; 14(2):229-43. PMC: 88972. DOI: 10.1128/CMR.14.2.229-243.2001. View

Leandro C, Santos-Gomes G, Campino L, Romao P, Cortes S, Rolao N . Cell mediated immunity and specific IgG1 and IgG2 antibody response in natural and experimental canine leishmaniosis. Vet Immunol Immunopathol. 2001; 79(3-4):273-84. DOI: 10.1016/s0165-2427(01)00270-7. View

Moll H, Berberich C . Dendritic cell-based vaccination strategies: induction of protective immunity against leishmaniasis. Immunobiology. 2002; 204(5):659-66. DOI: 10.1078/0171-2985-00105. View

Borja-Cabrera G, Correia Pontes N, da Silva V, Paraguai de Souza E, Santos W, GOMES E . Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (São Gonçalo do Amarante, RN). Vaccine. 2002; 20(27-28):3277-84. DOI: 10.1016/s0264-410x(02)00294-3. View

Moreno J, Alvar J . Canine leishmaniasis: epidemiological risk and the experimental model. Trends Parasitol. 2002; 18(9):399-405. DOI: 10.1016/s1471-4922(02)02347-4. View

10.

Molano I, Garcia Alonso M, Miron C, Redondo E, Requena J, Soto M . A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum. Vet Immunol Immunopathol. 2003; 92(1-2):1-13. DOI: 10.1016/s0165-2427(02)00315-x. View

11.

Ramiro M, Zarate J, Hanke T, Rodriguez D, Rodriguez J, Esteban M . Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK. Vaccine. 2003; 21(19-20):2474-84. DOI: 10.1016/s0264-410x(03)00032-x. View

12.

Reithinger R, Coleman P, Alexander B, Vieira E, Assis G, Davies C . Are insecticide-impregnated dog collars a feasible alternative to dog culling as a strategy for controlling canine visceral leishmaniasis in Brazil?. Int J Parasitol. 2004; 34(1):55-62. DOI: 10.1016/j.ijpara.2003.09.006. View

13.

Mohebali M, Khamesipour A, Mobedi I, Zarei Z, Hashemi-Fesharki R . Double-blind randomized efficacy field trial of alum precipitated autoclaved Leishmania major vaccine mixed with BCG against canine visceral leishmaniasis in Meshkin-Shahr district, I.R. Iran. Vaccine. 2004; 22(29-30):4097-100. DOI: 10.1016/j.vaccine.2004.03.058. View

14.

Alvar J, Canavate C, Molina R, Moreno J, Nieto J . Canine leishmaniasis. Adv Parasitol. 2004; 57:1-88. DOI: 10.1016/S0065-308X(04)57001-X. View

15.

Chamizo C, Moreno J, Alvar J . Semi-quantitative analysis of cytokine expression in asymptomatic canine leishmaniasis. Vet Immunol Immunopathol. 2005; 103(1-2):67-75. DOI: 10.1016/j.vetimm.2004.08.010. View

16.

Rafati S, Nakhaee A, Taheri T, Taslimi Y, Darabi H, Eravani D . Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum. Vaccine. 2005; 23(28):3716-25. DOI: 10.1016/j.vaccine.2005.02.009. View

17.

Sher A, Coffman R . Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol. 1992; 10:385-409. DOI: 10.1146/annurev.iy.10.040192.002125. View

18.

Fernandez-Bellon H, Solano-Gallego L, Rodriguez A, Rutten V, Hoek A, Ramis A . Comparison of three assays for the evaluation of specific cellular immunity to Leishmania infantum in dogs. Vet Immunol Immunopathol. 2005; 107(1-2):163-9. DOI: 10.1016/j.vetimm.2005.04.002. View

19.

Solano-Gallego L, Llull J, Ramis A, Fernandez-Bellon H, Rodriguez A, Ferrer L . Longitudinal study of dogs living in an area of Spain highly endemic for leishmaniasis by serologic analysis and the leishmanin skin test. Am J Trop Med Hyg. 2005; 72(6):815-8. View

20.

Ferroglio E, Maroli M, Gastaldo S, Mignone W, Rossi L . Canine leishmaniasis, Italy. Emerg Infect Dis. 2005; 11(10):1618-20. PMC: 3366729. DOI: 10.3201/eid1110.040966. View