MRI Evaluation of the Relationship Between Carotid Artery Endothelial Shear Stress and Brain White Matter Lesions in Migraine

Overview

Journal J Cereb Blood Flow Metab

Publisher Sage Publications

Specialties Cardiology & Vascular Diseases
Endocrinology
Neurology

Date 2019 Jun 20

PMID 31213163

Citations 13

Authors

Evelien S Hoogeveen

Enrico B Arkink

Jeroen van der Grond

Mark A van Buchem

Michel D Ferrari

Gisela M Terwindt

Mark C Kruit

Affiliations

Soon will be listed here.

Abstract

Although white matter lesions are frequently detected in migraine patients, underlying mechanisms remain unclear. Low carotid artery endothelial shear stress has been associated with white matter lesions. We aimed to investigate the association between carotid artery endothelial shear stress and white matter lesions in migraine. In 40 elderly migraine patients ( = 29 females, 75 years [SD 3]) and 219 controls ( = 80 females, 74 years [SD 3]) from the PROSPER-MRI study, carotid artery endothelial shear stress was estimated on 1.5 T gradient-echo phase contrast MRI. White matter lesion volumes were calculated from structural MRI scans. Analyses were adjusted for age, sex, cardiovascular risk factors and cardiovascular disease. Migraine patients had lower mean endothelial shear stress compared to controls (0.90 [SD 0.15] vs. 0.98 [SD 0.16] Pa; = 0.03). The association between mean endothelial shear stress and white matter lesion volume was greater for the migraine group than control group ( for interaction = 0.05). Within the migraine group, white matter lesion volume increased with decreasing endothelial shear stress (β-0.421; = 0.01). In conclusion, migraine patients had lower endothelial shear stress which was associated with higher white matter lesion volume.

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References

Moskowitz M . Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology. 1993; 43(6 Suppl 3):S16-20. View

Tietjen G, Khubchandani J . Vascular biomarkers in migraine. Cephalalgia. 2014; 35(2):95-117. DOI: 10.1177/0333102414544976. View

van der Geest R, Niezen R, van der Wall E, de Roos A, Reiber J . Automated measurement of volume flow in the ascending aorta using MR velocity maps: evaluation of inter- and intraobserver variability in healthy volunteers. J Comput Assist Tomogr. 1998; 22(6):904-11. DOI: 10.1097/00004728-199811000-00013. View

van der Flier W, Middelkoop H, Weverling-Rijnsburger A, Admiraal-Behloul F, Spilt A, Bollen E . Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD. Neurology. 2004; 62(10):1862-4. DOI: 10.1212/01.wnl.0000125337.65553.8a. View

Widlansky M, Gokce N, Keaney Jr J, Vita J . The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003; 42(7):1149-60. DOI: 10.1016/s0735-1097(03)00994-x. View

Launer L, Terwindt G, Ferrari M . The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology. 1999; 53(3):537-42. DOI: 10.1212/wnl.53.3.537. View

Jeong S, Lee J, Rosenson R . Association between Ischemic Stroke and Vascular Shear Stress in the Carotid Artery. J Clin Neurol. 2014; 10(2):133-9. PMC: 4017016. DOI: 10.3988/jcn.2014.10.2.133. View

Dreier J, Reiffurth C . The stroke-migraine depolarization continuum. Neuron. 2015; 86(4):902-922. DOI: 10.1016/j.neuron.2015.04.004. View

Ziegler T, Bouzourene K, Harrison V, Brunner H, Hayoz D . Influence of oscillatory and unidirectional flow environments on the expression of endothelin and nitric oxide synthase in cultured endothelial cells. Arterioscler Thromb Vasc Biol. 1998; 18(5):686-92. DOI: 10.1161/01.atv.18.5.686. View

10.

Box F, Spilt A, van Buchem M, van der Geest R, Reiber J . Automatic model-based contour detection and blood flow quantification in small vessels with velocity encoded magnetic resonance imaging. Invest Radiol. 2003; 38(9):567-77. DOI: 10.1097/01.RLI.0000077125.58014.36. View

11.

Lee W, Jung K, Ryu Y, Lee K, Kim J, Lee S . Progression of Cerebral White Matter Hyperintensities and the Associated Sonographic Index. Radiology. 2017; 284(3):824-833. DOI: 10.1148/radiol.2017162064. View

12.

Stam A, Weller C, Janssens A, Aulchenko Y, Oostra B, Frants R . Migraine is not associated with enhanced atherosclerosis. Cephalalgia. 2012; 33(4):228-35. DOI: 10.1177/0333102412466966. View

13.

Shepherd J, Blauw G, Murphy M, Cobbe S, Bollen E, Buckley B . The design of a prospective study of Pravastatin in the Elderly at Risk (PROSPER). PROSPER Study Group. PROspective Study of Pravastatin in the Elderly at Risk. Am J Cardiol. 1999; 84(10):1192-7. DOI: 10.1016/s0002-9149(99)00533-0. View

14.

Swartz R, Kern R . Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol. 2004; 61(9):1366-8. DOI: 10.1001/archneur.61.9.1366. View

15.

Jickling G, Salam A, Mohammad A, Hussain M, Scozzafava J, Nasser A . Circulating endothelial progenitor cells and age-related white matter changes. Stroke. 2009; 40(10):3191-6. DOI: 10.1161/STROKEAHA.109.554527. View

16.

Liu Y, Lu M, Zhu Y, Stemerman M, Chien S, Shyy J . Shear stress activation of SREBP1 in endothelial cells is mediated by integrins. Arterioscler Thromb Vasc Biol. 2002; 22(1):76-81. DOI: 10.1161/hq0102.101822. View

17.

Sacco S, Ripa P, Grassi D, Pistoia F, Ornello R, Carolei A . Peripheral vascular dysfunction in migraine: a review. J Headache Pain. 2013; 14:80. PMC: 3849862. DOI: 10.1186/1129-2377-14-80. View

18.

Okada Y, Kohara K, Ochi M, Nagai T, Tabara Y, Igase M . Mechanical stresses, arterial stiffness, and brain small vessel diseases: Shimanami Health Promoting Program Study. Stroke. 2014; 45(11):3287-92. DOI: 10.1161/STROKEAHA.114.006539. View

19.

Hassan A, Hunt B, OSullivan M, Parmar K, Bamford J, Briley D . Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain. 2003; 126(Pt 2):424-32. DOI: 10.1093/brain/awg040. View

20.

Dreier J, Ebert N, Priller J, Megow D, Lindauer U, Klee R . Products of hemolysis in the subarachnoid space inducing spreading ischemia in the cortex and focal necrosis in rats: a model for delayed ischemic neurological deficits after subarachnoid hemorrhage?. J Neurosurg. 2000; 93(4):658-66. DOI: 10.3171/jns.2000.93.4.0658. View