Aberrant MicroRNA Expression and Its Implications for Uveal Melanoma Metastasis

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2019 Jun 20

PMID 31212861

Citations 25

Authors

Kyra N Smit

Jiang Chang

Kasper Derks

Jolanda Vaarwater

Tom Brands

Rob M Verdijk

Erik A C Wiemer

Hanneke W Mensink

Joris Pothof

Annelies de Klein

Emine Kilic

Affiliations

Soon will be listed here.

Abstract

Uveal melanoma (UM) is the most frequently found primary intra-ocular tumor in adults. It is a highly aggressive cancer that causes metastasis-related mortality in up to half of the patients. Many independent studies have reported somatic genetic changes associated with high metastatic risk, such as monosomy of chromosome 3 and mutations in . Still, the mechanisms that drive metastatic spread are largely unknown. This study aimed to elucidate the potential role of microRNAs in the metastasis of UM. Using a next-generation sequencing approach in 26 UM samples we identified thirteen differentially expressed microRNAs between high-risk UM and low/intermediate-risk UM, including the known oncomirs microRNA-17-5p, microRNA-21-5p, and miR-151a-3p. Integration of the differentially expressed microRNAs with expression data of predicted target genes revealed 106 genes likely to be affected by aberrant microRNA expression. These genes were involved in pathways such as cell cycle regulation, EGF signaling and EIF2 signaling. Our findings demonstrate that aberrant microRNA expression in UM may affect the expression of genes in a variety of cancer-related pathways. This implies that some microRNAs can be responsible for UM metastasis and are promising potential targets for future treatment.

Citing Articles

Uveal Melanoma: Comprehensive Review of Its Pathophysiology, Diagnosis, Treatment, and Future Perspectives.

Kulbay M, Marcotte E, Remtulla R, Lau T, Paez-Escamilla M, Wu K Biomedicines. 2024; 12(8).

PMID: 39200222 PMC: 11352094. DOI: 10.3390/biomedicines12081758.

Biological characteristics and clinical management of uveal and conjunctival melanoma.

Kastelan S, Didovic Pavicic A, Pasalic D, Nikuseva-Martic T, canovic S, Kovacevic P Oncol Res. 2024; 32(8):1265-1285.

PMID: 39055896 PMC: 11267116. DOI: 10.32604/or.2024.048437.

Exploring of miR-155-5p, miR-181b-5p, and miR-454-3p Expressions in Circulating Cell-Free RNA: Insights from Peripheral Blood of Uveal Malignant Melanoma Patients.

Masoumeh H, Tunay D, Demet O, Samuray T, Hulya Y Biochem Genet. 2024; .

PMID: 38914847 DOI: 10.1007/s10528-024-10849-8.

Genetic and Epigenetic Features of Uveal Melanoma-An Overview and Clinical Implications.

Pasalic D, Nikuseva-Martic T, Sekovanic A, Kastelan S Int J Mol Sci. 2023; 24(16).

PMID: 37628989 PMC: 10454135. DOI: 10.3390/ijms241612807.

MiR-181a-5p inhibits uveal melanoma development by targeting GNAQ and AKT3.

Wang R, Tahiri H, Yang C, Landreville S, Callejo S, Hardy P Am J Cancer Res. 2023; 13(1):293-306.

PMID: 36777504 PMC: 9906069.

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