A Diet Including Xanthan Gum Triggers a Pro-inflammatory Response in Wistar Rats Inoculated with Walker 256 Cells

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2019 Jun 19

PMID 31211796

Citations 2

Authors

Alessandra B Silva Rischiteli

Nelson I P Neto

Karina Gascho

Marcela Carnier

Danielle A de Miranda

Fernanda P Silva

Valter T Boldarine

Marilia Seelaender

Eliane B Ribeiro

Lila M Oyama

Claudia M Oller do Nascimento

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study was to evaluate the effect of adding xanthan gum to the diet of rats on the production of cytokines and pro-inflammatory factors and on tumor development in rats inoculated with Walker 256 tumor cells.

Methods: Fifty-six rats were divided into 4 groups: control diet (C), control diet with tumor (TC), xanthan gum diet (XG), xanthan gum diet with tumor (TXG).

Results: The ingestion of xanthan gum promotes changes in cytokine content: increasing IL-6 TNF-α and IL-10 in retroperitoneal adipose tissue compared to the control group; and increasing TNF-α in the mesenteric adipose tissue compared to the C and TXG groups. On the contrary, the addition of xanthan gum to the diet did not affect the development of Walker 256 tumors in rats.

Conclusion: The continuous use of xanthan gum triggered a pro-inflammatory response, promoting an increase in pro-inflammatory cytokines in the adipose tissue, but it did not have an effect on the tumor development in the animals inoculated with Walker 256 tumor cells.

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