Prevalence of Dysphagia in Multiple Sclerosis and Its Related Factors: Systematic Review and Meta-analysis

Overview

Journal Iran J Neurol

Publisher Tehran University of Medical Sciences

Date 2019 Jun 19

PMID 31210903

Citations 15

Authors

Alireza Aghaz

Alireza Alidad

Ehsan Hemmati

Hussein Jadidi

Leila Ghelichi

Affiliations

Soon will be listed here.

Abstract

Dysphagia is the most prevalent sign of multiple sclerosis (MS) which can reduce the quality of life and augment mortality in the final stages of MS. We presented a systematic review to estimate the prevalence of dysphagia in general and separately for each evaluation method (subjective and objective), and to analyze the causes of this rampant disease. Cross-sectional and prospective cohort studies were reviewed and scientific proofs were evaluated consistent with the pre-specified levels of certainty. Twenty-two articles entered the meta-analysis phase; the estimation of the general prevalence of dysphagia in MS-affected patients was 43.33% related to all the 22 studies. Moreover, the estimate of the prevalence via the subjective (16 studies) and objective (6 studies) methods were 37.21% and 58.47%, respectively. This study obtained the prevalence rate of dysphagia in patients affected by MS globally, yet there was infinite statistical society and limited methodological quality. Thus, more extensive studies are required for a better understanding of the global epidemiology regarding dysphagia in MS.

Citing Articles

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References

Thomas F, Wiles C . Dysphagia and nutritional status in multiple sclerosis. J Neurol. 1999; 246(8):677-82. DOI: 10.1007/s004150050431. View

Calcagno P, Ruoppolo G, Grasso M, De Vincentiis M, Paolucci S . Dysphagia in multiple sclerosis - prevalence and prognostic factors. Acta Neurol Scand. 2002; 105(1):40-3. DOI: 10.1034/j.1600-0404.2002.10062.x. View

Wiesner W, Wetzel S, Kappos L, Hoshi M, Witte U, Radue E . Swallowing abnormalities in multiple sclerosis: correlation between videofluoroscopy and subjective symptoms. Eur Radiol. 2002; 12(4):789-92. DOI: 10.1007/s003300101086. View

de Pauw A, Dejaeger E, Dhooghe B, Carton H . Dysphagia in multiple sclerosis. Clin Neurol Neurosurg. 2002; 104(4):345-51. DOI: 10.1016/s0303-8467(02)00053-7. View

Terre-Boliart R, Orient-Lopez F, Guevara-Espinosa D, Ramon-Rona S, Bernabeu-Guitart M, Clave-Civit P . [Oropharyngeal dysphagia in patients with multiple sclerosis]. Rev Neurol. 2004; 39(8):707-10. View

Bergamaschi R, Crivelli P, Rezzani C, Patti F, Solaro C, Rossi P . The DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis. J Neurol Sci. 2008; 269(1-2):49-53. DOI: 10.1016/j.jns.2007.12.021. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

Poorjavad M, Derakhshandeh F, Etemadifar M, Soleymani B, Minagar A, Maghzi A . Oropharyngeal dysphagia in multiple sclerosis. Mult Scler. 2010; 16(3):362-5. DOI: 10.1177/1352458509358089. View

Butcher L . MS: Prevalence, Economics, and the Pipeline. Biotechnol Healthc. 2012; 5(3):6-7. PMC: 2706182. View

10.

Danesh-Sani S, Rahimdoost A, Soltani M, Ghiyasi M, Haghdoost N, Sabzali-Zanjankhah S . Clinical assessment of orofacial manifestations in 500 patients with multiple sclerosis. J Oral Maxillofac Surg. 2012; 71(2):290-4. DOI: 10.1016/j.joms.2012.05.008. View

11.

Alfonsi E, Bergamaschi R, Cosentino G, Ponzio M, Montomoli C, Restivo D . Electrophysiological patterns of oropharyngeal swallowing in multiple sclerosis. Clin Neurophysiol. 2013; 124(8):1638-45. DOI: 10.1016/j.clinph.2013.03.003. View

12.

Solaro C, Rezzani C, Trabucco E, Amato M, Zipoli V, Portaccio E . Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). J Neurol Sci. 2013; 331(1-2):94-7. DOI: 10.1016/j.jns.2013.05.020. View

13.

Fernandes A, Duprat A, Eckley C, Silva L, Ferreira R, Tilbery C . Oropharyngeal dysphagia in patients with multiple sclerosis: do the disease classification scales reflect dysphagia severity?. Braz J Otorhinolaryngol. 2013; 79(4):460-5. PMC: 9442424. DOI: 10.5935/1808-8694.20130082. View

14.

Sales D, Alvarenga R, Vasconcelos C, Silva R, Thuler L . Translation, cross-cultural adaptation and validation of the Portuguese version of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis. Springerplus. 2013; 2:332. PMC: 3728525. DOI: 10.1186/2193-1801-2-332. View

15.

Levinthal D, Rahman A, Nusrat S, OLeary M, Heyman R, Bielefeldt K . Adding to the burden: gastrointestinal symptoms and syndromes in multiple sclerosis. Mult Scler Int. 2013; 2013:319201. PMC: 3791579. DOI: 10.1155/2013/319201. View

16.

Guan X, Wang H, Huang H, Meng L . Prevalence of dysphagia in multiple sclerosis: a systematic review and meta-analysis. Neurol Sci. 2015; 36(5):671-81. DOI: 10.1007/s10072-015-2067-7. View

17.

Beckmann Y, Gurgor N, Cakir A, Arici S, Kurt Incesu T, Secil Y . Electrophysiological Evaluation of Dysphagia in the Mild or Moderate Patients with Multiple Sclerosis: A Concept of Subclinical Dysphagia. Dysphagia. 2015; 30(3):296-303. DOI: 10.1007/s00455-015-9598-1. View

18.

Goncalves M, Franca C, Fragoso Y, Deana A, de Almeida L, Bussadori S . Orofacial evaluation in patients with multiple sclerosis using Nordic Orofacial Test-Screening. Clin Oral Investig. 2016; 21(5):1681-1685. DOI: 10.1007/s00784-016-1952-7. View

19.

Pajouh S, Moradi N, Shaterzadeh Yazdi M, Latifi S, Mehravar M, Majdinasab N . Diagnostic evaluation of dysphagia in multiple sclerosis patients using a Persian version of DYMUS questionnaire. Mult Scler Relat Disord. 2017; 17:240-243. DOI: 10.1016/j.msard.2017.08.012. View

20.

Shibasaki H, McDonald W, Kuroiwa Y . Racial modification of clinical picture of multiple sclerosis: comparison between British and Japanese patients. J Neurol Sci. 1981; 49(2):253-71. DOI: 10.1016/0022-510x(81)90083-6. View