Autophagy-Independent Functions of the Autophagy Machinery

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2019 Jun 15

PMID 31199916

Citations 410

Authors

Lorenzo Galluzzi

Douglas R Green

Affiliations

Soon will be listed here.

Abstract

Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism that culminates with the lysosomal degradation of superfluous or potentially dangerous cytosolic entities. Over the past 2 decades, the molecular mechanisms underlying several variants of autophagy have been characterized in detail. Accumulating evidence suggests that most, if not all, components of the molecular machinery for autophagy also mediate autophagy-independent functions. Here, we discuss emerging data on the non-autophagic functions of autophagy-relevant proteins.

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